摘要
利用高分辨液体NMR技术考察了D2O中β-环糊精与手性药物D/L-樟脑磺酸对映体之间的相互作用,结果表明樟脑磺酸对映体能够进入β-环糊精的疏水空腔并与之发生手性相互作用.β-环糊精能够手性识别樟脑磺酸对映体.化学计量关系实验和2D ROESY实验结果表明,樟脑磺酸对映体的疏水结构只能从β-环糊精疏水空腔的宽口端进入,并形成化学计量比为1∶1的非对映体络合物.
Chiral recognition of β-cyelodextrin （β-CD） to chiral drug D/L-10-camphoric sulfonic acid （CSA） was investigated using high resolution liquid-state NMR spectroscopy. It was found that CSA can enter the hydrophobic cavity of β-CD and interact with it chirally. The results of 2D ROESY experiments suggested that the enantiomers of CSA enter into the hydrophobic cavity of β-CD from its wide brim, not from its narrow brim. Stoichiometry result showed a 1：1 complex between the host and the guest. It was demonstrated that β-CD can be used to discriminate the enantiomers of CSA.
出处
《波谱学杂志》
CAS
CSCD
北大核心
2009年第4期457-465,共9页
Chinese Journal of Magnetic Resonance
基金
国家自然科学基金资助项目(10474116
10674152)
