摘要
目的：探索牛磺酸对应激性心肌损伤的保护机理。方法：以异丙肾上腺素（ＩＳＯ）诱导的大鼠应激为模型，测定应激大鼠血清和心肌中Ｔ３、Ｔ４水平及心肌与肝脏中Ｔ４５－脱单碘酶（Ｔ４５－ＤＩ）活性的变化。结果：ＩＳＯ组大鼠血清、心肌中Ｔ３水平及心肌与肝脏中Ｔ４５－ＤＩ活性显著高于对照组，Ｔ４水平显著低于对照组；而牛磺酸组除血清中Ｔ３和心肌中Ｔ４５－ＤＩ活性显著高于对照组、低于ＩＳＯ组外，血清中Ｔ４和心肌中Ｔ３、Ｔ４水平及肝脏中Ｔ４５－ＤＩ活性与对照组未见显著差异。结论：牛磺酸可通过纠正应激大鼠甲状腺激素代谢亢进来减轻Ｔ３过量所致心肌能源耗竭，保护心肌免受应激损伤。
Isoproterenol (ISO) induced acute stress in rats was adopted as a model and content of thyroid hormone (T 3、T 4) in serum and myocardium, T 4 5 DI activity in myocardium and liver were measured. As compared with the control group, T 3 in serum and myocardium, T 4 5 DI activity in myocardium and liver of ISO group were significantly increased, while T 4 in serum and myocardium was significantly reduced. When taurine was injected, it could significantly inhibit above changes caused by ISO. Conclusion:Taurine could protect myocardium from stress induced damage by inhibiting hypermetabolism of thyroid hormone and alleviating energy exhaustion by excessive production of T 3 in stressed rats.
出处
《营养学报》
CAS
CSCD
北大核心
1998年第4期413-415,共3页
Acta Nutrimenta Sinica
