摘要
目的:研究在老年病人胃癌根治术后肠外营养(PN)中应用ω-3多不饱和脂肪酸(ω-3 PUFA)的作用。方法:将40例老年胃癌切除术后病人随机分为试验组和对照组,每组20例。对照组病人按低氮、低热量原则给予PN治疗,试验组加用ω-3 PUFA。比较两组病人营养指标、免疫指标、肝功能变化、炎性反应指标和并发症的发生率等。结果:试验组病人并发症的发生率为5%,对照组为20%,差异有显著性意义(P<0.05)。术后经5 d的治疗,试验组病人PA水平、体液免疫和细胞免疫指标、IgA、IgG含量和CD4细胞均显著高于对照组(P<0.05,P<0.01)。两组病人术后第1天IL-6、TNF-α和CRP水平均升高。第5天后,试验组IL-6、TNF-α和CRP显著低于对照组(P<0.05)。对照组病人肝功指标明显升高,与试验组相比有显著性差异(P<0.05)。结论:ω-3 PUFA可通过阻断过度炎性反应、调节病人免疫功能和保护器官功能等作用,有利于老年胃癌病人术后的康复。
Objective:To investigate the clinical effect of ω-3 polyunsaturated fatty acids (ω-3 PUFA) on elder patients after gastric cancer radical operation. Methods: Forty patients were randomly divided into experimental group(EG) and control group(CG), The patients of CG were treated with hypocalorie and lower nitrogen parenteral nutrition, and those in EG received ω-3 PUFA additionally. The nutrition index, immune function, liver function, inflammatory reaction and complications were compared. Results: The rate of complications significantly decreased in the EG (20% vs 5%, χ^2 = 3. 958, P 〈 0.05). There were no significant differences in albumn and hemoglobin between the two groups (P 〉 0.05 ). The level of prealbumin was significantly increased in the EG. The humoral immunity and cellular immunity were higher in the EG than those in the CG. IL-6, TNF-α and CRP levels on postoperatiw, d5 were significantly depressed in the EG. Conclusion: Postoperative supplementation of ω-3 PUFA may have a favorable effect on the outcomes in elder gastric cancer patients.
出处
《肠外与肠内营养》
CAS
北大核心
2009年第6期328-331,共4页
Parenteral & Enteral Nutrition
关键词
胃癌
Ω-3脂肪酸
免疫功能
Gastric cancer
ω-3 polyunsaturated fatty acids
Immune function