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基于无创血糖检测的传感器集成设计 被引量:4

Design of integrating sensors based on non-invasive blood sugar measuring
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摘要 根据能量代谢守恒法无创检测血糖浓度的原理,设计出一规格为60 mm×30 mm×85.5 mm的无创血糖检测传感器集成器。主要由底座、指表血流流速检测区、人体指部代谢率检测区、指端血氧红外检测区、电路连接区和信号输入输出区组成。由温度传感器、湿度传感器、辐射温度传感器、双波长(660 nm/905 nm)的红外发射及接收传感器在一定实施条件下集成得到。通过本集成器实现了对血糖浓度的无创伤检测,经20例临床初步实验,结果表明:与AMS-AUTOLAB18全自动生化分析仪的相关系数R达到了0.807,具有较好的相关性和一致性。经误差统计分析发现其平均相对误差为7.0%,平均绝对误差小于0.5,证明检测结果具有较高的精确度。 Based on the method of conservation of energy metabolism (COEM), an integrator of sensors is designed to measure the blood sugar level non-invasively,which size is 60 mm ×30 mm×85.5 mm. Including the base, the blood flow measuring region of the finger surface, the metabolism rate measuring region of the part of finger, the oxygen saturation infrared measuring region of the part of finger, the link region of circuit and the signal in-out region. The integrator is integrated by the temperature sensors, the humidity sensors, the radiation sensors, the dual emitter photodetectors (660 nm/905 nm)at some implementary conditions. Blood sugar level is achieved non-invasively by the integrator. The results of 20 preliminary clinical experimentations suggest that the correlative coefficient is up to 0. 807 between the integrator and automatic biochemical analyzer(AUTOLAB18), which shows strong correlation and good coherence. The average relative error is 7.0 %, and the boundary of average relative different is less than 0.5 through the statistical error analysis, which shows the measuremental results is effective and accurate.
出处 《传感器与微系统》 CSCD 北大核心 2009年第12期74-76,79,共4页 Transducer and Microsystem Technologies
基金 湖南省自然科学基金资助项目(07JJ6133)
关键词 无创血糖检测 能量代谢守恒法 传感器设计 集成器 non-invasivc glucose measuring conservation of energy metabolism sensor design integrator
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参考文献11

  • 1陈真诚,龚琼,王弟亚,徐效文,朱健铭,金星亮.基于能量守恒的无创血糖检测传感器的设计[J].传感技术学报,2008,21(5):724-728. 被引量:9
  • 2陈真诚,金星亮,徐效文,朱健铭,王弟亚.一种无创血糖检测仪的初步研究[J].传感技术学报,2008,21(7):1119-1123. 被引量:9
  • 3孙斐,孔德义,梅涛,陶永春.无创伤法测量血糖浓度的技术及其发展前景[J].生物医学工程学杂志,2005,22(1):171-174. 被引量:12
  • 4Tamada Janet A, Satish Grag. Non-invasive glucose monitoringcomprehensive clinical results [ J ]. JAMA,1999 (282) : 1839 -1844.
  • 5Tierney M J, Tamada J A, Potts R O, et al. Clinical evaluation of the glucowatch biographer:A continual, non-invasive glucose monitor for patients with diabetes [ J ]. Biosensors and Bio-electronics,2001,16 (9 -12 ) :621 -629.
  • 6Marbach R,Koschinsky T H, Gries F A,et al. Nominvasive glucose assay by near-infrared diffuse reflectance spectroscopy of the human inner lip [ J ]. Appl Spectrosc, 1993 (47) :875 -881.
  • 7Xu Kexin, Qiu Qingjun, Jiang Jingying, et al. Non-invasive glucose sensing with near-infrared spectroscopy enhanced by optical measurement conditions reproduction technique [ J ]. Optics and Lasers in Engineering, 2005 (43) : 1096 -1106.
  • 8Katsuhiko Maruo, Mitsuhiro Tsurugi, Jakusei Chin, et al . Noninvasive blood glucose assay using a newly developed near-Infrared system[ J]. IEEE Journal of Selected Topics in Quantum E- Iectronics ,2003,9(2 ) :322 -330.
  • 9Cho Okkyung, Kim Yoonok , Schwerte D E. Blood sugar level measuring apparatus : United States, 2004/0225209 [ P ] . 2004-11-11.
  • 10Cho Okkyung, Kim Yoonok, Hiroshi Mitsumaki, et al. Non-inva-sive measurement of glucose by metabolic heat conformation method[ J]. Clinical Chemistry ,2004,50 ( 10 ) : 1894 -1898.

二级参考文献49

  • 1陈文亮,徐可欣,杜振辉,刘蓉,范世福.人体无创血糖检测技术[J].仪器仪表学报,2003,24(z1):258-261. 被引量:18
  • 2孙斐,孔德义,梅涛,陶永春.无创伤法测量血糖浓度的技术及其发展前景[J].生物医学工程学杂志,2005,22(1):171-174. 被引量:12
  • 3刘志宏.人体无创血糖检测方法的研究[J].中国科技信息,2006(02A):91-91. 被引量:4
  • 4Cameron BD,Cote GL. Polatimetric detection of chiral chemicals in biological fluids. Proceedings of the SPIE International Biomedical Optics Conference,1997;2982:308-313.
  • 5Cote GL,Cameron BD. Noninvasive polarimetric measurement of glucose in cell culture media. Journal of Biomedical Optics,1997;2:275.
  • 6Hutchinson DP.Person glucose monitor. US Patent,1991:No5009230.
  • 7Cote GL, Fox MD. IEEE Transactions on Biomedical Engineering,1992;39:752.
  • 8Kohl M,Essenpreis M,Cope M. The influence of glucose concentration upon the transport of light in tissue-simulation phantoms. Phys Med Biol,1995;40:1267.
  • 9David C. Noninvasive blood glucose monitoring. Diabetes Care,1997;20:433.
  • 10张镜如 乔健天 生理学.第四版[M].北京:人民卫生出版社,1997.55-56.

共引文献30

同被引文献33

  • 1李俊峰,唐飞,徐效文,王东生.热传递法无创测量血液流速[J].仪器仪表学报,2006,27(z2):1178-1180. 被引量:3
  • 2王建军,孙万蓉,张旭.通过频谱分析测量血氧饱和度[J].生物医学工程研究,2004,23(3):167-169. 被引量:4
  • 3于巍,张宁,姚翔,邓亲恺.血氧饱和度检测中自动增益控制方法的研究[J].医疗卫生装备,2006,27(2):7-8. 被引量:6
  • 4King H, Aubert R E, Herman W H. Global Burden of Diabetes 1995-2025 : Prevalence, Numerical Estimates and Projections [ J ]. .Diab. Care,1998, (21) :1414-1431.
  • 5Ok-Kyung Cho, Yoon-Ok Kim, Schwerle (DE). Blood Sugar Level Measuring Apparatus [ P ]. United States :2004/0225209,2004.
  • 6Ok Kynng Cho, Yoon Ok Kim, Hiroshl Mitsamaki, et 81. Noninvasive Measurement of Glucose by Metabolic Heat Conformation Method [ J ]. Clinical Chemistry,2004,50 ( 10 ) : 1894 - 1898.
  • 7Tavakoli M,Turicchia L,Sarpeshkar R.An ultra-low-power pluse oximeter implemented with an energy-efficient transimpedance amplifier[J].IEEE Transactions on Biomedical Circuits and Systems,2010,4(1):27-38.
  • 8Sandeep K V.Non-invasive glucose monitoring technology in diabetes management:A review[J].Analytica Chimica Acta,2012,750(10):16-27.
  • 9Miguel P,Hermann L T,Werner M.Infrared spectroscopic analysis of human interstitial fluid in vitro and in vivo using FT-IR spectroscopy and pulsed quantum cascade lasers(QCL):Establishing a new approach to non-invasive glucose measurement[J].Spectrochimica Acta Part A:Molecular and Bio-molecular Spectroscopy,2012,85(1):61-65.
  • 10Chen Z C,Jin X L,Zhu J M,et al.Non-invasive glucose measuring apparatus based on conservation of energy method[J].J Cent South Univ Technol,2009,16:982-986.

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