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家兔腹主动脉易损斑块模型制作的实验研究 被引量:5

Preparation of vulnerable plaques in abdominal aorta:an experimental study in rabbits
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摘要 目的建立家兔腹主动脉易损斑块模型。方法选取30只雄性纯种新西兰大白兔,随机分为3组:球囊损伤+高脂喂养组、高脂喂养组及普通饲料喂养组。饲养12周后分别给予中国斑点蝰蛇毒和组胺药物触发,诱发斑块破裂及血栓形成。结果内膜损伤+高脂喂养组存活的8只兔中有10处病变狭窄程度超过50%,并且脂质核心较大、纤维帽厚度小于65μm,判定以上10处病变为易损斑块。高脂喂养组中的9只仅3处可判定为易损斑块;普通饲料喂养组中未见易损斑块。结论高脂喂养后行腹主动脉球囊拉伤制作兔易损斑块模型是切实可行的方法。 Objective To establish an animal model of vulnerable plaque in abdominal aorta by pharmacological triggering of atherosclerosis in rabbits.Methods Thirty New Zealand white rabbits were randomly and equally divided into 3 groups: group A,receiving balloon injury together with high lipid diet;group B,receiving high lipid diet only,and group C,receiving regular diet only.After feeding for 12 weeks,all the rabbits in three groups underwent pharmacological triggering with Chinese Russell’s viper venom(CRVV) and histamine to induce the rupture of the plaque and the formation of thrombosis.Results In 8 survival rabbits of group A,ten lesions with the stenotic degree over 50% were found,which had large lipid core with the thickness of fibrous cap being thinner than 65μm,by which these ten lesions were judged as vulnerable plaques.In 9 rabbits of group B,only 3 vulnerable plaques could be determined,while no single vulnerable plaque could be identified in the rabbits of group C.Conclusion For establishing an animal model of vulnerable plaque in abdominal aorta in rabbits,balloon injury combined with high lipid diet is a feasible and reliable method.
出处 《介入放射学杂志》 CSCD 北大核心 2009年第11期856-860,共5页 Journal of Interventional Radiology
关键词 腹主动脉 易损斑块 球囊 动脉粥样硬化 abdominal aorta vulnerable plaque balloon atherosclerosis
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  • 1Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II [J]. Circulation. 2003, 108: 1772- 1778.
  • 2Shiomi M, Ito T, Yamada S, et al. Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit) [J]. J Atheroscler Thromb, 2004, 11 : 184 - 189.
  • 3Johnson JL, Jackson CL. Atheroselerotic plaque rupture in the apolipoprotein E knockout mouse[J]. Atherosclerosis, 2001, 154:399 - 406.
  • 4靳亚非,郑振声,马虹,杜志民,胡瑞德,詹橙扬,陶军,郑树森,戴刚,冯吉,梁陆光,钱月桃,方典秋.体外反搏慢性实验对高脂饲养猪动脉粥样硬化斑块形成的干预作用[J].介入放射学杂志,2003,12(S1). 被引量:3
  • 5Yanni AE. The laboratory rabbit: an animal model of atherosclerosis research[J]. Lab Anita, 2004, 38:246 - 256.
  • 6Forster BA, Weinberg PD. Changes with age in the influence of endogenous nitric oxide on transport properties of the rabbit aortic wall near branches[J]. Arterioscler Thromb Vasc Biol, 1997, 17:1361 - 1368.
  • 7Haunstetter A, Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease[J]. Circ Res, 1998, 82: 1111 - 1129.
  • 8Yamashita A, Furukoji E, Marutsuka K, et al.Increased vascular wall thrombogenicity combined with reduced blood flow promotes occlusive thrombus formation in rabbit femoral artery [J]. Arterioscler Thromb Vasc Biol, 2004, 24: 2420- 2424.
  • 9Chen WQ, Zhang Y, Zhang M, et al. Establishing an animal model of unstable atherosclerotic plaques [J]. Chin Med J (Engl), 2004, 117:1293 - 1298.
  • 10Phinikaridou A, Hallock KJ, Qiao Y, et al. A robust rabbit model of human atherosclerosis and atherothrombosis[J]. J Lipid Res, 2009, 50: 787- 797.

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