摘要
目的:评价吉西他滨+顺铂联合放疗序贯治疗中晚期鼻咽癌患者的疗效及其毒副反应,探讨中晚期鼻咽癌新的综合治疗方案。方法:采用常规放疗联合GP化疗方案序贯治疗中晚期(Ⅲ和ⅣA)鼻咽癌患者80例,吉西他滨800mg/m2,静脉滴入,d1、d8;DDP15mg/m2,静脉滴入,d1～d5,每4周重复,共4个周期,并行常规放疗。评价其近远期疗效及毒副反应。结果:经治疗后80例患者鼻咽及颈部病灶均完全消失,病例随访≥3年。毒副反应主要表现骨髓抑制及胃肠道反应,尤其以血小板下降为明显。1、2和3年生存病例分别为80、78和78例;1例1年内复发,1例1年内发生骨转移并于首诊后16个月死亡,1例1～2年内发现复发转移并死亡;其余77例未发现复发转移。结论:吉西他滨+顺铂化疗联合放疗治疗中晚期鼻咽癌疗效显著,值得临床应用。
OBJECTIVE：To evaluate the efficacy and toxicity of chemotherapy regimen of gemcitabine plus cisplatin sequently combined with radiotherapy for advanced nasopharyngeal carcinoma. METHODS： Total 80 patients with advanced nasopharyngeal cancer（Ⅲ and ⅣA） were enrolled in this study of chemotherapy regimens （gemcitabine 800 mg/m2,d1,d8;cisplatin 15 mg/m2,d1-d5,4 weeks as on cycle;and sequently regular radiotherapy）. The early response,long-term effects and side effects of GP chemotherapy were analyzed. RESULTS：All the patients accepted the treatments of GP＋RT got complete response. The main side-effects were neutropenia and thrombocytopenia. In follow-up of 3 years,there were 80,78,78 cases survived within 1,2 and 3 years respectively;One case was found recurrence in one year;One patient was found recurrence and metastasis in 2 years and died;and one patient was found multiple osteometastatisis in one year and died 16 months after the disease confirmed. The other 77 patients were survival and had no the evidence of recurrence or metastasis. CONCLUSION：The chemotherapy regimen of gemcitabine plus cisplatin sequently combined with radiotherapy for advanced nasopharyngeal carcinoma has positive effects.
出处
《中华肿瘤防治杂志》
CAS
2009年第18期1412-1414,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
广东省科技计划项目基金(社会发展)
项目编号2006B36002026及2007B030700001
