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活性氧调控肿瘤转移

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摘要 肿瘤转移是一个复杂的病理过程,包括肿瘤细胞侵袭机体正常组织、肿瘤细胞进入血管或淋巴管到达远处组织、肿瘤细胞在远处组织停留并继续形成新的肿瘤灶等多个环节。本文从活性氧(ROS)与肿瘤转移的关系、活性氧主要来源、活性氧调控的信号通路几个方面综述。
作者 孙超 丰昌平 郑秋生 王振华
机构地区 石河子大学药学院新疆特种植物药资源教育部重点实验室 江西省南昌市现代教育技术中心
出处 《农垦医学》 2009年第5期454-456,共3页 Journal of Nongken Medicine
基金 国家自然科学基金(30760058)
关键词 活性氧 肿瘤转移 信号通路
分类号 R73-37 [医药卫生—肿瘤]
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参考文献20

  • 1Chiarugi P. PTPs versus PTKs:The redox side of the coin[ J]. Free Radical Research,2005,39 ( 4 ) : 353-364.
  • 2Okamoto A, Iwamoto Y, Maru Y. Oxidative stress-responsive transcription factor ATF3 potentially mediates diabetic angiopathy [ J ]. Mol Cell Biol,2006,26(3) :1087-97.
  • 3Inoguchi T,Takayanagi R. Role of oxidative stress in diabetic vascular complications [ J ]. Fukuoka Igaku Zasshi, 2008,99 ( 3 ) : 47- 55.
  • 4Ishikawa K, Takenaga K, Akimoto M, et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis [ J ]. Science,2008,320(5876) :661-664.
  • 5Wu W S,Tsai R K, Chang C H,et al. Reactive oxygen species mediated sustained activation of protein kinase C α and ERK for migration of humanhepatoma cell HepG2 [ J ]. Molecular Cancer Research,2006,4(10) :747-758.
  • 6Hyoudou K, Nishkawa M, Kobayashi Y, et al. SOD derivatives prevent metastatic tumor growth aggravatedby tumor removal [ J ]. Clin Exp Metastasis ,2008,25 (5) :531-536.
  • 7Connor K M, Subbaram S, Regan K J, et al. Mitochondrial H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation [ J ]. The Journal of Biology Chemistry,2005,280(17) :16916-16924.
  • 8Ikeda S, Ushio-Fukai M,Zuo L,et al. Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis [J]. Circ. Res. 2005,96(4) :467-475.
  • 9仇万山,陈亦江.线粒体结构、功能和常用研究方法[J].国际麻醉学与复苏杂志,2007,28(3):282-285. 被引量：22
  • 10van Waveren C, Sun Y, Cheung H S, et al. Oxidative phosphorylation dysfunction modulates expression of extracellular matrix-remodeling genes and invasion [ J ]. Carcinogenesis, 2006,27 ( 3 ) : 409-418.

二级参考文献16

  • 1刘树森．线粒体医学及其分子基础．细胞生物学动态．北京，北京师范大学出版社，1999，135—153．
  • 2Kiberstis PA.Mitochondria make a comeback.Science,1999,283,5407: 1475.
  • 3Crompton M.The mitochondrial permeability transition pore and its role in cell death.Biochem J,1999,341:127-132.
  • 4Frey TG, Mannella CA.The internal structure of mitochondria. Trends Biochem Sci, 2000,25:319-324.
  • 5Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell, 2003,112:481-490.
  • 6Ferrari R, Pedersini P, Bongrazio M, et al. Mitochondrial energy production and cation control in myocardial ischaemia and reperfusion. Basic Res Cardiol, 1993,88:495-512.
  • 7Gunter TE, Gunter KK, Sheu SS, et al. Mitochondrial calcium transport: physiological and pathological relevance. Am J Physiol, 1994,267:C313 -C339.
  • 8Robb-Gaspers LD, Rutter GA, Bumett P, et al. Coupling between cytosolic and mitochondrial calcium oscillations: role in the regulation of hepatic metabolism. Biochim Biophys Acta, 1998,1366:17-32.
  • 9Gunter TE, Buntinas L, Sparagna GC, et al. The Ca^2+ transport mechanisms of mitochondria and Ca^2+ uptake from physiologicaltype Ca^2+ transients. Biochim Biophys Acta, 1998,1366:5-15.
  • 10Abramova NE, Davies KJ, Crawford DR. Polynucleotide degradation during early stage response to oxidative stress is specific to mito chondria. Free Radic Biol Med, 2000,28:281-288.

共引文献21

农垦医学
2009年 第5期

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