摘要
目的探讨外科手术联合自体骨髓干细胞动员治疗重型颅脑损伤的疗效及安全性。方法回顾分析56例重型颅脑损伤患者的临床资料。结果外科手术联合自体骨髓干细胞动员治疗组重型颅脑损伤患者NIH神经功能缺损评分(NIHSS)(8.07±7.91)显著低于外科手术对照组(15.89±9.61)分(t=5.074,P<0.01),而治疗组格拉斯哥预后评分(GOS)结果显著好于对照组(X^2=4.383,P<0,05),且治疗组未出现严重不良反应。结论外科手术联合自体骨髓干细胞动员治疗重型颅脑损伤安全有效,可显著改善患者神经功能和预后。
Objective To explore the effect and safety of treatment for patients with severe traumatic brain injury by surgical operation combined with autologous bone marrow stem cell mobilization. Methods A retrospective analysis was conducted in 56 cases with severe traumatic brain injury. Results The NHISS score（8.07±7.91） of patients in the treatment group by surgical operation combined with autologous bone marrow stem cell mobilization was significantly lower than that（15.89±9.61） in the control group by surgical operation only（ t = 5. 074 ,P 〈 0.01）. The GOS showed that the prognosis of the treatment group was significantly better than that of the control group （X^2=4.383 ,P 〈0.05）. No severe adverse events were noted in the treatment group. Conclusion The treatment of patients with severe traumatic brain injury by surgical operation combined with autologous bone marrow stem cell mobilization is safe and effective. It can promote the functional recovery of the brain and ensure favorable prognosis in patients with traumatic brain injury.
出处
《医学研究杂志》
2009年第12期46-48,共3页
Journal of Medical Research
基金
河南省杰出人才计划项目(084200410011)
关键词
创伤性脑损伤
手术
骨髓干细胞
动员
治疗
Traumatic brain injury
Operation
Bone marrow stem cell
Mobilization
Treatment
