摘要
目的:观察初发甲状腺功能亢进的Graves病(GD)以及经他巴唑治疗、甲状腺功能正常后患者不同时间血清可溶性白介素2受体(sIL-2R)水平变化,探讨sIL-2R与GD之间的关系。方法:按临床表现及其生化指标选取14例未做任何治疗的初发GD患者(A组),男5例,女9例;B组为经他巴唑治疗甲状腺功能正常后GD患者22例,男9例,女13例,继续服用他巴唑1、6、12个月;C组为健康献血者18例,男8例,女10例。分别检测各组受试者血清sIL-2R、TT3、TT4水平。结果:A组血清sIL-2R、TT3、TT4浓度较B组和C组显著增高(P<0.01);A组sIL-2R浓度与TT3呈正相关(γ=0.8536,P<0.01)。B组与C组的sIL-2R、TT3、TT4水平差异无统计学意义。结论:GD患者sIL-2R水平反映了体内甲状腺激素水平,是GD活动程度的指标之一。
Objective ：To observe the changes of sIL - 2R level in patients with first - episode Graves＇disease（GD） as well as in those receiving methimazole treatment at different time after their thyroid function became normal, and to explore the relationship between sIL - 2R and GD. MethodS：According to clinical manifestation and biochemical indicators, 14 cases of first - episode GD without any treatment were selected as group A （ male = 5, female = 9 ）. In group B,22 GD patients were orally given methimazole and continuously treated for 1,6,12 months after their thyroid function were normal （male = 9, female = 13 ） . 18 normal persons were selected as control （ group C, male = 8, female = 10）. The sIL - 2R levels of all subjects were measured by ELISA. Their TT3 and TY4 level were also detected. Results ： The levels of sIL - 2R, T3 and T4 were higher in group A than those in group B and C （ P 〈 0.01 ）. In group A, sIL - 2R was positively correlated with T3 （ 7 = 0. 8536, P 〈 0.01 ）. No statistic differences of slL - 2R,T4 and T3 were found between group B and group C. Conclusion：The sIL - 2R can reflect the levels of thyroid hormone in GD patients with hyperthyreosis. It is a marker of the thyroid activity of GD patients.
出处
《西南国防医药》
CAS
2009年第12期1192-1194,共3页
Medical Journal of National Defending Forces in Southwest China
