摘要
目的：探讨血脂、载脂蛋白与冠心病冠状动脉狭窄程度之间的关系。方法：对本诊冠心病而行选择性冠状动脉造影的４４６例住院患者，进行吸烟、饮酒、高血压和糖尿病情况的回顾性分析，比较患者的血脂、血浆载脂蛋白水平，进一步分析血脂、载脂蛋白与冠心病冠状动脉狭窄程度之间的关系。结果：冠状动脉有病变组与无病变组患者的血浆高密度脂蛋白胆固醇、低密度脂蛋白胆固醇无显著差异，而血清总胆固醇、甘油三酯、血浆载脂蛋白Ａ１、载脂蛋白Ｂ水平在冠状动脉有病变组与无病变组间存在显著差异（Ｐ＜００１）。Ｓｐｅａｒｍａｎ等级相关分析表明，只有年龄、血清总胆固醇、甘油三酯和血浆载脂蛋白Ｂ水平与冠状动脉狭窄程度成正相关（γ＝０１９２３～０２７０２，Ｐ＜００１）。Ｌｏｇｉｓｔｉｃ回归分析显示，年龄、性别、高胆固醇、高载脂蛋白Ｂ血症、低水平高密度脂蛋白胆固醇为冠心病冠状动脉狭窄发生发展的独立危险因素（ＯＲ＝０２０～８８１，Ｐ＜００１）。结论：年龄、血清总胆固醇、甘油三脂和载脂蛋白Ｂ水平与冠状动脉狭窄程度呈正相关。高龄、性别、高胆固醇、载脂蛋白Ｂ血症、低水平高密度脂蛋白胆固醇为影响冠状动脉狭窄的独立因素。
Objective:To understand the relationship between blood lipid apolipoprotein and the severity of coronary artery stenosis in patients with coronary heart disease(CHD).Methods:Four hundred and fortysix admitted patients with suspected CHD were studied retrospectively.All the patients underwent coronary angiography,survey of smoking,drinking,hypertension,diabetes mellitus and examination of lipid,lipoprotein and apolipoprotein during the hospitalization,Subsequently,the relationship between blood lipid,apolipoprotein and the severity of coronary artery stenosis was determined.Results:The plasma high density lipoprotein cholesterol(HDLC) levels and low density lipoprotein cholesterol levels in patients with CHD was not significantly different from those in the normal subjects separately, but a significant difference of total cholesterol(CHD),triglyceride(TG) and apolipoprotein B(APOB) levels was observed between these two groups on the basis of the Spearman correlation analysis.Through Logistic regression analysis,gender,advanced age,hypercholesterolemia,high level of APOB,low level of HDL-C were confirmed to be independent risk factors for CHD and for the severity of coronary artery stenosis(OR=020-881,P<001).Conclusion:Gender,advanced age,hypercholesterolemia,high level of APOB,low level of HDLC in plasma are independent risk factors for CHD,and the severity of coronary artery stenosis is positively related to the level of plasma total CHO,TG and APOB.
出处
《中日友好医院学报》
1998年第3期239-243,共5页
Journal of China-Japan Friendship Hospital
