摘要
目的:观察腹腔镜下阑尾切除术对小儿细胞免疫功能的影响。方法:对40例慢性阑尾炎患儿,随机分为腹腔镜组和开腹组,分别于术前及术后1d、3d监测T细胞亚群CD3+、CD4+、CD4+/CD8+的变化。结果:与术前比较,术后1d两组CD3+、CD4+显著降低(P<0.05),而CD8+明显升高(P<0.05),CD4+/CD8+比值降低(P<0.01),术后3d均恢复至正常水平。但LA组术后1d的CD8+升高幅度及CD3+、CD4+、CD4+/CD8+比值降低幅度均明显低于OA组(P<0.05或P<0.01)。结论:开腹或腹腔镜下阑尾切除术均可抑制小儿细胞免疫功能,但腹腔镜手术对细胞免疫功能的影响相对较小。
Objective To observe the change of cellular immune function in children proceeding laparoscopie appendecto- my. Method Forty children with chronic appendicitis were randomly divided into two groups： the laparoscope group （LA group） and the operation abdomen group：（ OA group） ,210 cases in each group. CD3^＋ ,CD4^＋ and CD4^＋/CD8^＋ in vein were determined before operation and 1 d,3d after operation. Results Compared with that of before operation, CD3^＋ and CD4^＋ of ld after operation decreased markedly in both groups （ P 〈 0. 05 ）, but CD8^＋ increased significantly （ P 〈 0. 05 ）, and CD4^＋/CD8^＋ decreased markedly （ P 〈 0. 01 ）. All indexes of 3d after operation returned to normal level. The increasive degree of CD8^＋ and decreasive degree of CD3^＋, CD4^＋, CD4^＋/CD8^＋ in LA group was lower than that in OA group（ P 〈 0. 05 or P 〈 0.01 ）. Conclusion Different operations including operation abdomen or laparoscopic appendectomy can suppress cellular immune function in children,bet the effect of laparoscope is smaller than that of abdomen operation.
出处
《吉林医学》
CAS
2009年第23期2934-2936,共3页
Jilin Medical Journal
关键词
腹腔镜
阑尾切除术
小儿
细胞免疫
Laparoscope
Appendectomy
Children
Cellular immune
