摘要
目的:了解淮安市β-内酰胺类抗菌药物药品不良反应(ADR)发生情况,分析其影响因素,以促进临床合理用药。方法:对淮安市2007年收集的619例β-内酰胺类抗菌药物ADR报告分别从患者年龄、性别、给药途径、使用药物种类以及临床表现等方面进行统计分析。结果:涉及β-内酰胺类抗菌药物共33种,以阿莫西林居首位,其次为青霉素钠;以静脉途径给药引发的ADR最多;临床表现以皮肤及其附件损害最常见。结论:规范β-内酰胺类抗菌药物的临床应用,避免或减少ADR的发生。
Objective： To comprehend the reality and affecting factors of adverse drug reactions （ADR） induced by β-lactam antibiotics in Huai＇an city, in order to promote the proper use of drug in clinic. Methods ： We collected 619 cases of ADR induced by β-lactam antibiotics and analyzed them with the aspects of patient＇s age and gender, adminstration route, species of drugs and clinical manifestation. Results： The ADR were caused by a total of 33 species of β-lactam antibiotics agents, among which amoxicillin ranked the first and was followed by penicillin sodium. The most causing route was intravenous administration; the damage of skin and its annex were the most common clinical manifestations. Conclusions ： The clinical application of β-lactam antibiotics of should be regulated to avoid or reduce the occurrence of ADR.
出处
《药学与临床研究》
2009年第6期505-508,共4页
Pharmaceutical and Clinical Research
