摘要
流行病学研究证实遗传因素在发育性髋关节发育不良（developmentaldysplasiaofthehip，DDH）发病中具有重要作用。研究发现67．88％的DDH与遗传因素有关，32．12％的DDH与环境因素有关。目前有关该病诊断和治疗方面的研究已得到不断发展，但在遗传病因学方面仍未有明确结论。本文就髓关节发育不良候选基因及其定位研究的进展作一简要综述。
Epidemiological studies have confirmed that genetic factors play an important role in the incidence of developmental dysplasia of the hip （DDH）. Previous studies showed that genetic factors accounted for a major part （about 67.88%）, the remaining part was due to the environmental factors. At present, great progress has been made in the researches of the diagnosis and treatment of DDH, but there is no clear conclusion in the genetic etiology. This article reviews the latest studies of candidate genes and their mapping.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2009年第6期674-677,共4页
Chinese Journal of Medical Genetics
关键词
发育性髋关节发育不良
遗传学
易感基因
遗传多态性
developmental dyspiasia of the hip
genetics
susceptibility gene
genetic polymorphism
