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特发性肺纤维化的分子发病机制及靶向药物研究进展 被引量：4

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摘要 特发性肺纤维化（IPF）足以肺间质胶原过度沉积和纤维母细胞过度增生为特征的慢性肺部疾病，其预后很差，5年生存率仪为20％。IPF的传统治疗方案主要是采用糖皮质激素联合免疫抑制剂，但明显获益的临床证据并未见报道。随着人们对肺纤维化发病机制的认识不断深入，逐渐产生一些针对IPF发生、发展过程的细胞信号传导和其他生物学途径中的关键部位设计的靶向药物，笔者在此对靶向药物的研究进展进行综述。
作者 张坚 徐作军 朱元珏
机构地区 中国医学科学院北京协和医学院北京协和医院呼吸内科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2009年第12期945-947,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
关键词 特发性肺纤维化 分子发病机制 靶向药物 药物研究进展 联合免疫抑制剂 慢性肺部疾病 细胞信号传导 纤维母细胞
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献27

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同被引文献62

  • 1Saketkoo LA,Matteson EL,Brown KK.Developing disease activity and response criteria in connective tissue disease-related interstitial lung disease[J].J Rheumatol,2011,38:1514-1518.
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引证文献4

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中华结核和呼吸杂志
2009年 第12期

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