摘要
目的:探讨异丙酚联合舒芬太尼用于儿童纤维胃镜检查的可行性和安全性。方法:接受胃镜检查者120例,随机分为芬太尼组(F组)和舒芬太尼组(S组),每组60例,分别静脉注射咪达唑仑0.05 mg/kg、阿托品0.01 mg/kg,F组给以芬太尼1μg/kg,S组给以舒芬太尼0.1μg/kg,两组给予异丙酚2 mg/kg,待患儿睫毛反射消失后插入胃镜,记录麻醉诱导前、置镜时、手术结束时的心率(HR)、平均动脉压(MAP)、脉搏氧饱和度(SPO2),同时记录注射部位是否疼痛、完全清醒时间、术中不适、术后舌后坠、恶心呕吐、眩晕以及两组异丙酚用量等。结果:F组在置镜时HR、MAP高于麻醉诱导前(P<0.05),术中最低SPO2低于麻醉诱导前(P<0.05);S组HR、MAP在各时点差异无统计学意义(P>0.05),术中最低SPO2低于麻醉诱导前(P<0.05)。组间比较,麻醉诱导前两组HR、MAP、SPO2差异无统计学意义,置镜时S组HR、MAP低于F组(P<0.05),术中最低SPO2高于F组(P<0.05),注射部位疼痛、完全清醒时间、术中不适、眩晕以及异丙酚的总用量均低于F组(P<0.05)。结论:异丙酚联合舒芬太尼麻醉用于儿童纤维胃镜检查,HR、MAP更平稳,呼吸抑制轻,苏醒质量高。
Objective： To investigate the feasibility and clinic effect of anesthesia with propofol-sufentanil in gastrofiberscopy in children. Methods：One hundred and twenty patients scheduled for elective gastrofiberscopy were randomized into two groups：group fentanyl （F） and group sufentanil（S） （n =60）. group F were given intravenou midazolam 0.05 mg/kg, atropine 0.01 mg/kg, fentanyl 1 μg/kg, propofol 2 mg/kg, group S were given intravenou midazolam 0.05 mg/kg,atropine 0.01 mg/kg, sufentanil 0.01 μg/kg, propofol 2 mg/kg. The gastrofiberscope was inserted after lash reflex had been extinct. Total dose of propofol, heart rate （HR）, mean arterial pressure （MAP）, pulse oxygen saturation （SpO2）,time of full recovery （answering correctly and walking without aid）,discomfort self-feeling were recorded and nausea and vomiting or dinus were noted. Results： At insertion of gastrofiberscope there was significant difference between MAP and HR in group F（P 〈0.05 ）, There was no significant difference in MAP and HR in group S（P〉 0.05 ）. Compared with group F, there was sig- nificant difference in MAP, HR, SpO2 at insertion of gastrofiberscope in group S （P 〈 0.05 ）. Pain, dose of propofol, time of full recovery, discomfort self-feeling in group S were lower than those in group F. Conclusion： More stable HR and MAP lower respiratory depression, better recovery were achieved in children receving gastrofiberscopy with propofol-sufentanyl as anesthesis.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2009年第11期1600-1602,共3页
Journal of Chongqing Medical University
