摘要
目的探讨血常规参数血小板2/(单核细胞百分比×分叶中性粒细胞百分比)值(P2/MS)与肝纤维化的相关性。方法选择慢性肝炎(慢肝组)68例,肝硬化(肝硬化组)60例,共128例病人。其中,有病理诊断者33例。慢肝组68例中,有慢性乙肝者54例;肝硬化组60例中,乙肝肝硬化43例。采用全自动血细胞计数仪检测血常规,根据相关数据计算P2/MS值;以放射免疫法测定血清透明质酸(HA)、Ⅲ型前胶原肽(PⅢP);肝活检标本分别进行苏木精-伊红(HE)、网状纤维及Masson染色;统计学采用SPSS 11.0软件处理。结果①肝硬化组、乙肝肝硬化组的P2/MS值显著低于慢肝组及慢乙肝组;②肝硬化组及乙肝肝硬化组的HA显著高于慢肝组及慢乙肝组;③肝硬化组的PⅢP高于慢肝组;差异均有统计学意义。结论P2/MS值可作为反映慢性肝病患者发展到肝硬化的有效参数。
Objective To investigate the relationship between the square of platelet count/（ percentage of monocyte x percentage of segmented neutrophil） （p2/MS） and hepatic fibrosis. Methods 128 cases, among them 33 cases had pathologically diagnosis, were divided into chronic hepatitis group （68 cases） and cirrhosis group （60 cases）. The blood routines were detected by automatic blood cell counter, and the value of p2/MS was calculated by related data. The serum hyaluronic acid （HA） and procollagen type Ⅲpeptide （PⅢ P） were deteced by radioimmunoassay. Liver biopsy specimens were stained with Hematoxylin - Eosine （HE）, reticular fiber and Masson stain. Statistic data analyzed by SPSS 11.0 software.Results（1）@The p2/MS level in cirrhosis group is obviously lower than that in chronic hepatitis group. （2）The HA level in cirrhosis group is obviously higher than that in chronic hepatitis group. （3）The PⅢP level in cirrhosis group is higher than that in chronic hepatitis group. They all have statistical difference. Conclusion The level of p2/MS can be used as an effective index which could reflect the course from chronic liver disease to eirrhosis.
出处
《黑龙江医学》
2009年第12期891-893,共3页
Heilongjiang Medical Journal
关键词
血常规参数
肝纤维化
慢性肝炎
Routine blood parameter
Hepatic ~brosis
Chronic hepatitis
