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血浆同型半胱氨酸检测在肝硬化及肝癌患者中的临床价值 被引量:4

Detection of plasma homocysteine in patients with liver cirrhosis and liver cancer and its clinical value
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摘要 目的:探讨血浆同型半胱氨酸(Hcy)检测在肝硬化及肝癌患者中的临床价值和肝硬化患者随访2年后血浆Hcy含量的变化。方法:检测137例肝硬化患者、43例肝癌患者和50例对照组的血浆Hcy水平,肝硬化患者随访2年后再次检测血浆Hcy含量,对检测结果进行统计分析。结果:肝硬化及肝癌组Hcy水平明显升高,具有统计学意义(P<0.05或P<0.01),肝硬化患者随着Child-Pugh分级的升高而递增,而且肝癌组与肝硬化各级之间比较,A级、B级差异非常显著(P<0.01),C级差异显著(P<0.05),肝硬化患者首次检测的Hcy含量与随访2年后检测的Hcy含量自身比较,Hcy略有增加,呈升高趋势,但无统计学意义(P>0.05)。结论:肝硬化及肝癌病人随着肝细胞损害程度的逐渐加重,血浆Hcy水平逐渐升高,血浆Hcy是反映肝损伤程度较为敏感的生化指标之一,并且对肝硬化及肝癌的诊断、治疗、预后判断具有一定的指导意义。 Objective:To investigate the plasma homocysteine(Hcy) detected in patients with liver cirrhosis and liver cancer and the clinical value in patients with liver cirrhosis were followed up for 2 years after the change in plasma Hcy concentration.Methods:137 cases of liver cirrhosis,43 cases of liver cancer patients and 50 control group,plasma Hcy levels in patients with liver cirrhosis after 2 years follow-up testing of plasma Hcy levels of the test results for statistical analysis.Results:The liver cirrhosis and liver cancer group was significantly increased Hcy levels,with statistical significance(P0.05 or P0.01),liver cirrhosis patients with Child-Pugh classification and the incremental increase,and the group of liver cancer and liver comparison between the hardening at all levels,A-class,B-class difference was significant(P0.01),C-level significantly different(P0.05),first detected in patients with cirrhosis of the Hcy concentration and follow-up 2 years after the detection of Hcy content in their own comparison,Hcy increased slightly,the trend was rising,but no statistical significance(P 0.05).Conclusion:Patients with liver cirrhosis and the extent of damage to liver cells gradually increase,gradually increased the level of plasma Hcy and plasma Hcy is a reflection of the degree of liver injury is more sensitive biochemical indicator of,and the diagnosis of liver cirrhosis and liver cancer,treatment,prognosis has some significance.
出处 《中国卫生检验杂志》 CAS 2009年第12期2875-2876,共2页 Chinese Journal of Health Laboratory Technology
关键词 肝硬化 肝癌 同型半胱氨酸 CHILD分级 Liver cirrhosis Liver cancer Homocysteine Child classification
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参考文献4

  • 1石胜,陈健勇,黄华兴,卢岑.血浆同型半胱氨酸水平与肝硬化严重程度的相关性研究[J].实用医学杂志,2004,20(5):530-531. 被引量:19
  • 2Hankey GJ, Eikelboom JW, HO WK, et al. Clinical usefulness of plasma homocysteine in vascular disease [ J ]. Mde J Aust, 2004,181 ( 6 ) : 314 -318.
  • 3Stead LM, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat liver[ J]. Biochem J ,2000,350(3 ) :685 -692.
  • 4Garcia - Tevijano ER, Berasain G, Rodriguez JA, et al. Hyperhomocys teinemia in liver cirrhosis:mechanisms and role in vascular and hepatic fibrosis[ J]. Hypertension,2001,38 (5) : 1217 - 1221.

二级参考文献6

  • 1Guba SC, Fink LM, Fonseca V. Hyperhomocysteinemia - an emerging and important risk factor for thromboembolic and cardiovascular disease.AM J Clin Pathol, 1996, 106(6):709-722
  • 2Houseton PE, Rana S, Sekhsaria S, et al. Homocysteine in sickle cell disease: relationship to stroke. AM J Med, 1997, 103(3):192- 196
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  • 4Mayer EL, Jacobsen DM, Robinson K. Homocysteine and coronary atheroselcrosis. JACC, 1996, 27(3) :517 - 527
  • 5Stead LM, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat liver. Biochem J, 2000, 350(3) :685 - 692
  • 6Garcia-Tevijano ER, Berasain C, Rodriguez JA, et al. Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis. Hypertension, 2001, 38(5): 1217 - 1221

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