摘要
目的研究甲状腺过氧化物酶抗体(ATA)和甲状腺球蛋白抗体(抗-Tg)在白癜风诊治中的应用价值。方法选择100例(男52例,女48例)白癜风患者和80例健康人(男38例,女42例)为研究对象,排除甲状腺疾病、甲状腺手术及接受甲状腺药物治疗的患者。2组对象的性别和年龄相当。所有对象都接受问卷调查,内容包括人口统计学资料,甲状腺疾病相关症状,皮肤表现和甲状腺功能检测结果。甲状腺功能检测项目包括促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)和ATA、抗-Tg。结果白癜风患者23例(23%)血清ATA升高,11例(11%)血清抗Tg升高;而对照组只有5例血清(6.3%)ATA升高,3例(3.8%)血清抗-Tg升高,病例组与对照组差异具有统计学意义(P<0.05)。病例组血清TSH水平为(1.59±1.25)U/L,对照组血清TSH水平为(1.14±1.08)U/L,差异具有统计学意义(P<0.05)。亚分组分析显示,性别、年龄和皮肤受累范围等与血清ATA、抗-Tg阳性率相关性的差异具有统计学意义(P<0.05)。白癜风的病程及其类型与ATA及抗-Tg阳性率不具有相关性。此外,病例组与对照组血清fT3、fT4水平的差异亦无统计学意义。结论血清ATA和抗-Tg可作为女性白癜风患者诊断和疗效观察的标志物,对血清ATA和抗-Tg水平升高的女性白癜风患者定期进行随访并检测甲状腺功能显得尤为重要。
Objective To investigate the applicable value of thyroid peroxidase antibody （ATA） and anti-thyroglobulin antibody （TgAb） in the diagnosis and therapeutic effect evaluation for patients with vitiligo. Methods One hundred cases of vitiligo （52 males, 48 females） and eighty healthy subjects （38 males, 42 females） were enrolled in this study. The patients who had a thyroid disease, his- tory of thyroid surgery or those receiving thyroid medications were excluded from the study. The subjects were matched in gender and age. The clinical data of these subjects were investigated by a questionnaire, including the demographic data, symptoms related to thyroid diseases and the manifestation of skin and thyroid examination. Thyroid function tests included TSH, free T3 （fT3）, free T4 （fT4） and ATA, TgAb were performed. Results There were statistical differences in increased cases （rate） of serum ATA and TgAb between vititigo group and healthy control group [23（23%） vs 5（6.3%）, 11 （11%） vs 3（3.8%）, respectively] （P〈0.05）. The difference in serum level of TSH （U/L） was significant （1.59 ± 1.25 vs 1.14 ± 1.08, P〈0.05）. Subgrouped analysis showed the difference in association of gender, age and involved skin area with positive rates of serum ATA and TgAb; however, there was no correlation between the course, types and positive rates of serum ATA and TgAb. In addition, there was no statistical difference in serum levels of fT3 and fT4 between vitiligo group and healthy control group. Conclusion Serum ATA and TgAb may be used as indicators of vitiligo diagno sis and therapeutic effect evaluation. It is extremely important to take a follow-up visit and monitor thyroid function parameters for vitiligo females with elevated levels of serum ATA and TgAb.
出处
《国际检验医学杂志》
CAS
2009年第12期1166-1168,共3页
International Journal of Laboratory Medicine
