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Th17细胞在炎性疾病中的作用 被引量：6

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摘要 Th17细胞是新近发现的一种CD4^+T细胞亚群,其主要产生的效应因子是IL-17。过去研究认为,Th1型的干扰素-γ和IL-12在组织炎性损伤中发挥重要作用。随着对Th17细胞的深入研究,发现其在介导慢性炎性反应和自身免疫性疾病发病机制中是关键的致病因素。本文简要对Th17细胞在炎性疾病中的促炎作用作一综述。
作者 陈颖 陈曲波
机构地区 广州中医药大学第二临床医学院免疫室
出处 《国际检验医学杂志》 CAS 2009年第12期1176-1177,1180,共3页 International Journal of Laboratory Medicine
基金 广东省社会发展领域科技计划项目(No.63020)
关键词 细胞 白细胞介素17 自身免疫疾病
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献15

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二级参考文献8

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共引文献13

同被引文献115

  • 1任劲松,潘修成,李丽,傅涓涓,辛杰晶,陈明,冯霞.慢性乙型肝炎患者外周血Th17细胞和IL-17检测及其临床意义[J].中华临床医师杂志（电子版）,2011,5(14):4264-4267. 被引量：12
  • 2屠毅,张立煌.NKT细胞在病毒性肝炎中的作用[J].国外医学（流行病学．传染病学分册）,2005,32(4):211-214. 被引量：3
  • 3观晓辉.内毒素、一氧化氮、白细胞介素—6在肝硬化并原发性腹膜炎中的临床意义[J].国际医药卫生导报,2005,11(18):14-15. 被引量：3
  • 4高苏俊,季晓辉.树突状细胞研究新突破——诱导免疫耐受[J].医学综述,2006,12(15):905-907. 被引量：2
  • 5Acosta-Rodriguez EV,Napolitani G,Lanzavecchia A,et al.Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells[J].Nat Immunol,2007,8(9):942-949.
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  • 8Veldhoen M,Hocking RJ,Atkins CJ,et al.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells[J].Immunity,2006,24(2):179-189.
  • 9Spolski R,Leonard WJ.The Yin and Yang of interleukin-21 in allergy,autoimmunity and cancer[J].Curr Opin Immunol,2008,20(3):295-301.
  • 10Wilson NJ,Boniface K,Chan JR,et al.Development,cytokine profile and function of human interleukin 17-producing helper T cells[J].Nat Immunol,2007,8(9):950-957.

引证文献6

二级引证文献66

国际检验医学杂志
2009年 第12期

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