摘要
为了探讨遗传因素与慢性阻塞性肺部疾病（ＣＯＰＤ）之间的关系，进一步提高人们对ＣＯＰＤ的环境病因和遗传病因的认识，收集了２０６个ＣＯＰＤ核心家系的资料。分析结果表明，ＣＯＰＤ的分离比为０．２７，ＣＯＰＤ属于多基因遗传；ＣＯＰＤ的遗传度为４４．４％，其中男性为４９．３％，女性为３８．８％。显示遗传因素在男性产生ＣＯＰＤ的过程中作用较大；但不论男性还是女性发生ＣＯＰＤ，遗传因素和环境因素。
To determine the relation between genetic factor and chronic obstructive pulmonary disease(COPD),we selected 206 COPD nuclear families and 206 control nuslear fanilies.The data of those families were analysed.The segregation retio of COPD was 0 27 and the genetic model of COPD belonged to polygenetics.The heritability of COPD was 44 4%,49 3% for male and 38 8% for female.It is concluded that genetic factor as the environmental factors is one of the risk factors for copd ,and is specially of imporrance for males.
出处
《中国公共卫生》
CAS
CSCD
北大核心
1998年第10期591-592,共2页
Chinese Journal of Public Health
