摘要
目的分析淤胆型肝炎的临床特征.方法对42例淤胆型肝炎病例进行回顾性调查,分析其临床资料,并与同期42例重型肝炎作比较.结果42例淤胆型肝炎患者,由肝炎病毒所致者31例,占73.8%;总胆红素(TBIL)水平(347.39±130.92)μmol/L,丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)水平14～1100μ/L、23～1265μ/L,与重型肝炎比较无统计学意义;出现重度乏力者1例、明显纳差者5例、陶土样大便12例,明显恶心呕吐1例,与重型肝炎比较有统计学意义;白蛋白(ALB)、总胆汁酸(TBA)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(γ-GT)、总胆固醇(CHOL)、空腹血糖(GLU)、凝血酶原时间(PT)水平分别为(39.83±5.31)g/L、(223.45±68.72)μmol/L、(196.31±83.24)U/L、(266.27±98.67)U/L、(4.87±1.36)mmol/L、(3.77±0.73)mmol/L、(14.59±1.58)s,与重型肝炎比较有统计学意义(P<0.05);B超检查淤胆型肝炎和重型肝炎差别无统计学意义(P>0.05).结论淤胆型肝炎的临床特征为:黄疸程度重而消化道症状不重;凝血酶原时间无明显延长;白蛋白及空腹血糖水平正常;总胆固醇正常或偏高;总胆汁酸、碱性磷酸酶、γ-谷氨酰转肽酶明显升高,可作为淤胆型肝炎和重型肝炎鉴别的重要依据.
Objective To analyse the clinical features of cholestatic hepatitis.Methods During the years of 2000～2009,42 cases with cholestatic hepatitis were treated in our department.We investigated retrospectively the clinical data,and compared with 42 cases of severe hepatitis in the same time.Results 31 out of 42 cases of cholestatic hepatitis were caused by the hepatitis virus,accounting for 73.8%;total bilirubin（TBIL）level of（347.39±130.92） μmol/L,alanine aminotransferase（ALT）,aspartate acid aminotransferase（AST）level of 14 ~ 1100 U/L,23 ~ 1265 U/L,compared with severe hepatitis,there was no statistical significance;severe weakness appeared in 1 case,significant anorexia in 5 cases,clay-like stool in 12 cases,significant nausea and vomiting in 1 case,compared with severe hepatitis,there was a statistical significance.Albumin（ALB）,total bile acid（TBA）,alkaline phosphatase（ALP）,γ-glutamyl GGT（γ-GT）,total cholesterol（CHOL）,fasting blood glucose（GLU）,blood clotting zymogen time（PT）levels respectively were（39.83 ± 5.31） g/L,（223.45± 68.72） μmol/L,（196.31±83.24） U/L,（266.27± 98.67） U/L,（4.87±1.36） mmol/L,（3.77±0.73） mmol/L,（14.59±1.58） s,compared with severe hepatitis,there was a statistical significance;the difference between B-ultrasound cholestatic hepatitis and fulminant hepatitis had no statistical significance.Conclusion Cholestatic hepatitis is characterized by the heavier degree of jaundice without obvious gastrointestinal symptoms,normal prothrombin time,albumin,and fasting blood glucose levels,normal or high total cholesterol,signifcantly high total bile acid,alkaline phosphatase,γ-glutamyltransferase,and GGT which can be used as an important basis for identification of cholestatic hepatitis and fulminant hepatitis.
出处
《昆明医学院学报》
2009年第11期123-125,共3页
Journal of Kunming Medical College
关键词
淤胆型肝炎
重型肝炎
临床特征
Cholestatic hepatitis
Severe hepatitis
Clinical characteristic
