摘要
目的:比较生肌中药内服、外用及内外合用治疗大鼠慢性难愈性创面疗效的差异。方法:60只大鼠随机分为正常组、模型组、中药内治组、中药外治组和中药合治组。采用腹腔注射糖皮质激素结合外科方法制备难愈性创面模型。各治疗组分别给予中药煎剂内服、白玉膏外用,观察各组大鼠创面愈合时间及创面愈合率。结果:第7天起模型组创面愈合率较正常组明显降低,总体创面愈合时间明显延长(P<0.01)。中药内治组、中药合治组第3、7、10、14天创面愈合率均高于模型组(P<0.05),中药外治组第3、14天创面愈合率高于模型组(P<0.05).且第7、10天内治组、合治组愈合率高于外治组(P<0.05)。中药内治组、中药合治组创面愈合时间较模型组明显缩短(P<0.05),且中药合治组优于中药内治组和中药外治组(P<0.05)。结论:生肌中药具有良好的促创面愈合作用,中药内外合用效果更佳。内服、外用及内外合用在创面炎症反应期具有良好促愈作用,而内服及内外合治在肉芽增生期及上皮爬生期的促愈作用也较明显。
Objective： To investigate the efficacy of oral, external and oral plus external application of recipes for promoting granulation on chronic skin ulcers in rats. Methods： Sixty SD male rats were randomly divided into normal group, untreated group, oral group, external group and combined group （ n = 12）. Chronic skin ulcer was induced by hydrocortisone injection and back skin incision. After oral administration of Fuzheng Huyu Recipe or （and） external application of Baiyu ointment, the compound traditional Chinese medicines for wound healing, healing time and healing rate of the ulcers were observed. Results： The healing rate was lower and the healing time was longer in the untreated group than in the normal group （P〈0.01）. The healing rates of the oral group and the combined group were higher than those of the untreated group at all observation points （P〈0. 05）, and the healing rate of the external group was higher on the 3rd and 14th day after model establishment （P 〈0. 05）. On the 7th and lOth day after model establishment, the healing rates of the oral group and the combined group were higher than those of the external group （P〈0.05）, and the healing time of the combined group was shorter than that of the oral group and external group （P〈0. 05）. Conclusion： Both orally and externally administered wound healing recipes can promote the restoration of chronic refractory ulcers; the effect of combined administration is superior to single administration. Oral,external and combined application can all improve the wound healing in inflammatory phase. Oral and combined application can obviously improve the wound healing in granulation phase and epithelial phase.
出处
《中西医结合学报》
CAS
2009年第12期1150-1153,共4页
Journal of Chinese Integrative Medicine
基金
上海市重点学科建设基金资助项目(No.T0304)
上海市青年科技启明星培养计划资助项H(No.03QBl4047)
