摘要
目的:探讨表皮生长因子受体-2(cerbB-2)在鼻咽癌组织中的表达情况及其意义。方法:采用免疫组织化学SP法检测cerbB-2在90例鼻咽癌组织和22例鼻咽炎性组织中的表达情况,分析cerbB-2表达水平与鼻咽癌临床病理因素的关系。结果:90例鼻咽癌组织中cerbB-2表达的阳性率为65.56%,22例鼻咽炎性组织中cerbB-2表达的阳性率为31.82%(P<0.05);鼻咽癌组CerbB-2表达在淋巴结分期N_2和N_3患者中阳性率为81.0%,N_0和N_1患者阳性率为52.1%(P<0.05),而与患者年龄、性别、临床分期、T分期和远处转移无明显相关(P>0.05)。结论:CerbB-2在鼻咽癌组织中高表达,它可能是鼻咽癌发生和发展过程中的一个重要因素。
Objective： To investigate the biological significance of CerbB-2 expression in nasopharyngeal carcinoma. Methods： The expression of CerbB-2 was detected in 90 nasopharyngeal carcinoma tissues and 22 nasopharyngitis tissues by SP immunohistochemical method. The relationship between CerbB-2 expression and clinicopathological characteristics of nasopharyngeal carcinoma was investigated. Results： The positive expression rate of CerbB-2 protein was 65.56% in nasopharyngeal carcinoma tissues, and 31.82% in nasopharyngitis tissues, with a significant difference （P〈0.05）. The ratio of expression was 81.0% in patients of N2 and N3 lymth node stage, significantly different from that in patients of N0 and N1 lymph node stage （52.1%, P〈0.05）. The expression of CerbB-2 gene was not correlated with age, gender, clinical stage, T stage and distant metastasis of nasopharyngeal carcinoma （P〉0.05）. Conclusion： There is a high expression of CerbB-2 in nasopharyngeal carcinoma tissues, which might be an important event in the pathogenesis and progression of nasopharyngeal carcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2009年第23期1350-1352,共3页
Chinese Journal of Clinical Oncology
基金
广西壮族自治区自然科学基金资助(编号:桂科自0640196)~~
