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不同时点应用帕瑞昔布对腹腔镜胆囊切除术后患者的影响 被引量:13

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摘要 目的:观察腹腔镜胆囊切除术患者应用帕瑞昔布的镇痛效果及超前镇痛作用。方法:90例择期行腹腔镜胆囊切除术的患者随机分为3组,每组30例。A组(n=30)为空白对照组。B组(n=30)在麻醉诱导后手术开始前静脉注射帕瑞昔布50 mg。C组(n=30)在胆囊取出后,关腹前静脉注射帕瑞昔布50 mg。观察术后0、2、8、24h的静息痛VAS评分和活动痛VAS评分,记录不良反应的发生,如恶心、呕吐、消化道出血、呼吸抑制等。结果:3组要求使用其他镇痛药物的患者数比较差异有显著性(P<0.05)。静息时,B组患者在术后2、8 h VAS评分低于A组;C组在术后即刻、术后2 h低于A、B组,在术后8 h低于A组(P<0.05)。活动时,B组在术后即刻及术后2、8 h的VAS评分均低于A组;C组在术后即刻、术后8 h低于A、B组,在术后2 h低于A组(P<0.05)。术后24 h 3组患者在静息和活动时的VAS评分差异无显著性(P>0.05)。3组患者并发症发生率的比较差异无显著性(P>0.05)。结论:帕瑞昔布在腹腔镜胆囊切除术前应用产生的镇痛效果比术后应用更好,同样具有超前镇痛的效应。
作者 唐江华
出处 《实用医学杂志》 CAS 北大核心 2009年第24期4215-4216,共2页 The Journal of Practical Medicine
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共引文献92

同被引文献84

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