摘要
目的探讨氟伏沙明与舍曲林治疗强迫症的临床疗效及不良反应。方法将58例强迫症患者随机分为两组,分别给予氟伏沙明和舍曲林治疗,疗程10周。采用Yale-Brown强迫量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、不良反应量表(TESS)评定临床疗效和不良反应。结果氟伏沙明组有效率为85.71%,舍曲林组为82.14%,两组比较无统计学意义(P>0.05);各组治疗后自第4周末Y-BOCS、HAMD、HAMA总分与治疗前比较差异有统计学意义。2组不良反应发生率比较无统计学意义(P>0.05)。结论氟伏沙明与舍曲林对强迫症均有较好的疗效,起效较快,不良反应少,患者耐受性好。
Objective To discuss the clinical efficacy and the adverse reactions of fluvoxamine and sertraline in the treatment of obsessive-compulsive disorder（OCD）. Methods A total of 58 patients who met the CCMD-3 criteria for OCD were randomly assigned to two groups. One group was treated with fluvoxamine and the other with sertraline for 10 weeks. The efficacy was measured with Yale -Brown Obsessive Compulsive Scale （Y- BOCS）, Hamilton Depression Scale（HAMD） and Hamilton Anxiety Scale（HAMA）. The adverse reactions were assessed by Treatment Emergent Symptoms SCale（TESS）. Results The improvement rate of fluvoxamine was 85.71%, and the improvement rate of sertraline was 82.14 %. There were no significant differences between two groups. According to the reducing scores of Y-BOCS, HAMD and HAMA, there were significant differences in the two groups from the fourth weekend. The adverse reaction of fluvoxamine was similar to that of sertraline. Conclusion Fluvoxamine and sertraline are effective antidepressants with few adverse reactions and patients can have good drug tolerance.
出处
《山东医学高等专科学校学报》
2009年第6期469-471,共3页
Journal of Shandong Medical College
关键词
氟伏沙明
舍曲林
强迫症
Fluvoxamine
Sertraline
Obsessive-compulsive disorder
