摘要
溶栓疗法是血栓治疗中的一种重要措施．研制具有高选择性的导向性纤溶酶原激活剂有着重大的理论意义和实用价值．采用血栓特异的单克隆抗体及其片段来介导溶栓剂已展示出较好的应用前景．双功能抗体以及同时具有抗栓，抗凝活性的小肽正逐渐拓宽人们有关导向分子研制的视野．
Thrombi targeted plasminogen activator has an important effect on thrombolysis . Some good results have been obtained by using monoclonal antibody or its fragments specific for fibrin or platelet to direct the plasminogen activator. Bispecific antibody and some peptides with properties of antithrombin or anticoagulation give new angle of view for targeted plasminogen activator.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1998年第5期429-433,共5页
Progress In Biochemistry and Biophysics
基金
国家"863"计划
关键词
纤溶酶原激活剂
血栓
纤维蛋白
抗体导向
导向性
thrombin targeted plasminogen activator , thrombi, platelet, fibrin, monoclonal antibody, bispecific antibody, single chain antibody, active peptides
