摘要
近年来国内外的学者在多种肿瘤中发现抑癌基因PTEN的等位基因缺失、基因突变、甲基化,PTEN基因杂合性丢失(LOH)频繁的发生于胃癌,而该基因发生突变的频率较低,蛋白表达普遍下降。抑癌基因PTEN异常与胃癌的发生和发展相关,对PTEN功能的进一步研究将为胃癌的诊断和治疗提供新的思路。
The gene mutation,deletion,methylation of tumor suppressor gene PTEN generally occurs in several types of tumors. While loss of heterozygosity（LOH） at the PTEN locus frequently occurs in Gastric tumor,the mutations of PTEN were not commonly found,but its expression was generally lower. The abnormality of PTEN may correlate with the development and progression of the Gastric tumor,Having a better understanding of the function of PTEN will provide new train of thought for the diagnosis and treatment of Gastric tumor.
出处
《现代生物医学进展》
CAS
2009年第21期4175-4178,共4页
Progress in Modern Biomedicine
关键词
胃癌
PTEN抑癌基因
Gastric Sarcoma
PTEN
tumor suppressor gene
