摘要
目的:探讨脊柱转移癌患者的预后因素、预计生存时间,为临床治疗方案的选择提供依据。方法:我院2004年1月～2006年6月收治并有随访资料的99例原发灶不同的恶性肿瘤发生脊柱转移的病例,将每位患者进行Tomita及Tokuhashi评分,并将上述两种评分及性别、年龄、病人一般状况(KPS)评分、原发肿瘤性质、脏器转移情况、骨转移情况等其它临床指标作为预后因素,进行单因素和多因素Cox回归分析,筛选预后因素。结果:单因素分析结果显示Tomita评分(P=0.008)、Tokuhashi评分(P=0.027)、原发肿瘤性质(P=0.000)以及KPS评分(P=0.005)是影响预后的独立因素。上述4个指标经多因素Cox回归分析结果显示,KPS评分(P=0.012)、原发肿瘤性质(P=0.000)影响预后的独立因素。结论:KPS评分、原发肿瘤性质可作为脊柱转移癌患者的预后指标,并且可通过预后指数评估预后,指导临床治疗。
Objective： To discuss the prognosis factor, estimating tile time of the patients with spinal col- umn metastases for selecting proper treatment method. Methods： From January 2004 to June 2006 admitted to our hospital and made follow-up visit material 99 cases of different malignant tumor to have case of illness which the spinal column metastatic. Tomita and the Tokuhashi grading were carried on each patient, and the above two grading and the sex, the age, the KPS grading, the primary tumor nature, the internal organs shift situation, the bone shift situation and so on other clinical targets takes the prognosis factor, carries on the single factor and the multi-factor Cox regression analysis, the screening prognosis factor. Results： The single factor analysis result showed Tomita grades （P=0. 008）, Tokuhashi grades （P = 0. 027）, primary tumor nature （P =0. 000）as well as KPS grades （P =0. 005） influence lifetime. After the multi-factors Cox regression analysis result indicated has KPS grades （P =0. 012） ,primary tumor nature （P =0. 000） affects the patient prognosis. Conclusion： KPS grades, primary tumor nature may the metastatic spinal tumors patient＇s prognosis factor, after and the passable regression model had appraised prognosis, finally instructs the clinical treatment.
出处
《新疆医科大学学报》
CAS
2009年第12期1653-1656,共4页
Journal of Xinjiang Medical University
关键词
脊柱转移癌
预后因素
COX回归模型
生存分析
the metastatic spinal tumors
prognosis factor
the COX regression model
survival analysis
