期刊文献+

新城疫病毒NP蛋白的分子生物学特征及其功能 被引量:3

下载PDF
导出
摘要 NP蛋白是新城疫病毒核衣壳蛋白的主要结构蛋白,其N端高度保守,与病毒基因组RNA直接结合,保护病毒基因组RNA免受RNA酶的降解。NP蛋白与基因组RNA共同组成NP-RNA复合体,作为复制和转录的模板,具有高度的免疫原性,能够介导细胞免疫作用。NP蛋白在研制特异免疫探针鉴别新城疫、人抗肿瘤以及研发新城疫病毒样颗粒疫苗等新型基因工程疫苗等方面具有广阔的发展前景。
出处 《江苏农业科学》 CSCD 北大核心 2009年第6期300-301,共2页 Jiangsu Agricultural Sciences
基金 衡水学院科研基金(编号:2005034)
  • 相关文献

参考文献17

  • 1Steward M, Vipond I B, Millar N S, et al. RNA editing in Newcastle disease virus [ J ]. J Gen Virol. 1993,74:2539 - 2547.
  • 2Bogoyavlenskiy A, Berezin V, Prilipov A, et al. Characterization of the nueleocapsid protein gene of Newcastle disease virus strains in Japan and development of a restriction enzyme - based rapid identifying method [ J ]. Arc Virol,2004,149 : 1559 - 1569.
  • 3Seal B S, Crawford J M, Sellers H S, et al. Nucleotide sequence analysis of the Newcastle disease virus nucleocapsid protein gene and phylogenetic relationships among the Paramyxaviridae [ J ]. Virus Res, 2002,83(1/2) :119 - 129.
  • 4王学理,王兴龙,李晓艳,任林柱,张辉,段小宇.新城疫病毒TL1株NP基因的遗传变异研究[J].中国病原生物学杂志,2007,2(2):89-92. 被引量:1
  • 5Egelman E H, Wu S S, Amrein M, et al. The Sendai virus nucleocapsidexists in at least four different helical states[ J ]. J Virol, 1989,63 ( 5 ) :2233 - 2243.
  • 6Calain P, Roux L. The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA[ J]. J Virol, 1993,67 : 4822 - 4830.
  • 7Pham H M, Chang K S, Mase M, et al. Molecular characterization of the nucleocapsid protein gene of Newcastle disease virus strains in Japan and development of a restriction enzyme - basedrapid identifying method [ J ]. Arch Virol,2004,149 : 1559 - 1569.
  • 8Peeters B P H,Gruijthuijsen Y K,de Leeuw O S,et al. Genome replication of Newcastle disease virus : involvement of the rule - of - six [ J ]. Arch Virol,2000,145 : 1829 - 1845.
  • 9Hamaguchi M, Yoshida T, Nichikawa K, et al. Transcriptive complex of Newcastle disease virus I. Both L and P proteins are required to constitute an active complex[ J]. Virology, 1983,128 : 105 - 117.
  • 10步志高,陈万芳.传染性支气管炎病毒结构蛋白及其免疫原性[J].国外兽医学(畜禽传染病),1998,18(1):7-10. 被引量:11

二级参考文献55

共引文献21

同被引文献41

  • 1刘华雷,周斌,郁斌,王永坤,陈溥言.五株鸽副粘病毒国内分离株F基因片段的克隆与分子特性[J].病毒学报,2004,20(4):378-381. 被引量:11
  • 2杨吉才,石国芳.鸽新城疫最新研究进展[J].中国动物保健,2005,7(9):34-36. 被引量:11
  • 3刘华雷,王志亮,吴延功,郑东霞,孙承英,宋翠平,左媛媛,王伟华.2005年中国新城疫病毒分子流行病学研究[J].畜牧兽医学报,2006,37(12):1340-1344. 被引量:32
  • 4王晓丽,夏兴霞,赵永前,褚玉梅,戴鼎震.鸽新城疫油乳剂灭活疫苗的研制[J].江苏农业学报,2007,23(2):109-113. 被引量:3
  • 5萨姆布鲁克J,拉塞尔D W,黄培堂,王嘉玺,朱厚础,等译.分子克隆实验指南[M]3版.北京:科学出版社,2002..
  • 6农业部畜牧兽医司.国际兽疫局(OIE)推荐的动物疫病诊断方法和生物制剂要求手册[R].北京:农业部畜牧兽医司,1992.33.
  • 7ALEXANDER D J,PARSONS G.Avian paramyxovims type Ⅰ infections of racing pigeons:2 pathogenicity experiments in pigeons and chickens[J].The Veterinary Record,1984,114(19):466-469.
  • 8MAYOM A. A summary of taxonomic changes recently approved by ICTV [J]. Arch Virol, 2002, 147(8):1655-1556.
  • 9CHEN J, LIAO M, REN T, et al. A goose-soured paramyxovirus isolated from southern China [ J]. Avian Disease,2005, 49 : 170- 173.
  • 10LIU X F, WANG H Q, NIX X, et al. Pathotypieal and genotyp- ical charaeteization of strains of Newcastled isease virus isolated from outbreaks in chicken and goose flocks in some regions of Chi- na during 1985-2001 [J]. Arch Virol, 2003, 148: 1387-1403.

引证文献3

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部