摘要
目的:探索缺氧诱导因子1α(HIF-1α)和诱导型一氧化氮合酶(iNOS)在胃癌组织中的表达水平及两者相关性。方法:采用免疫组化SP法检测85例胃癌组织和癌旁正常胃组织中的HIF-1α和iNOS的表达,并分析其相互关系。结果:HIF-1α和iNOS在胃癌组织中的表达水平(76.47%和71.76%)明显高于癌旁正常胃组织中(0)的表达水平(P=0.000),HIF-1α和iNOS的表达与胃癌的临床TNM分期、浸润程度和淋巴结转移有关(P<0.05),与组织学类型无关(P>0.05),HIF-1α的表达与iNOS的表达呈正相关r=0.761,P<0.05。结论:HIF-1α可能通过上调iNOS的蛋白表达促进肿瘤血管生成,HIF-1α与iNOS的高表达与胃癌的发生、浸润和转移密切相关。
OBJECTIVE：To investigate the significance of HIF-1α and iNOS expressions and their relationship with gastric carcinoma（GC）.METHODS：The SP immunohistochemical staining method was used to detect the expressions of HIF-1α and iNOS in 85 patients with gastic carinoma.RESULTS：The positive expression rates of HIF-1α and iNOS in GC（76.47% and 71.76%）were significantly higher than those in paired paracarcinoma（0,P=0.000）.Meanwhile,there was a significiat correlation of the expressions of HIF-1α and iNOS with the clinical TNM stage,invasive depth,lymph node metastasis（P0.05）except for the degree of differentiation（P0.05）.There was a certain positive correlation between HIF-1α and iNOS（r=0.761,P0.05）.CONCLUSION：HIF-1α and iNOS are associated with the development,invasion and metastasis of gastric carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2009年第20期1573-1575,共3页
Chinese Journal of Cancer Prevention and Treatment
