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社区中、老年人群高血压前期对颈动脉粥样硬化斑块形成的影响 被引量:8

The impact of prehypertension on carotid atherosclerotic plaque formation in a middle-aged and elderly community population
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摘要 目的探讨社区中、老年人群高血压前期与颈动脉粥样硬化斑块形成的关系。方法分别对942名46~75岁广州社区居民进行问卷调查、体格检查、血生化检验和双侧颈动脉超声检查,根据JNC-7的血压分类标准,比较正常血压(normotension,NT)、高血压前期(prehypertension,Pre-HT)和高血压(hypertension,HT)3亚组人群颈动脉粥样硬化斑块形成的差异。结果Pre-HT和HT均与高龄、男性、肥胖、血脂异常、吸烟的危险因素相关。控制相关危险因素后,Pre-HT颈动脉粥样硬化斑块形成是NT的2.37倍(95%CI:1.42~3.95,P<0.01),Pre-HT与HT之间颈动脉粥样硬化斑块形成的差异不明显(P>0.05)。与HT相比,Pre-HT颈动脉粥样硬化斑块以低回声斑块较多。结论高血压前期与颈动脉粥样硬化斑块形成风险增高相关,处于高血压前期的中、老年人群已存在较明显的靶器官损害——颈动脉粥样硬化斑块形成。 Objective To study the impact of prehypertension on carotid atherosclerotic plaque formation in a mid- die-aged and elderly population. Methods We studied nine hundred and forty-two residents in a community of Guang- zhou, China by questionnaires, physical examinations, blood chemistry tests and bilateral carotid ultrasonography. Differences of plaque formation were compared among the three populations of normotension (NT), prehypertension (Pre-HT) and hypertension ( HT), which were stratified by the JNC-7 classification of blood pressure. Results Pre-HT and HT were associated with the risk factors such as older age, male gender, dyslipidemia, obesity and smoking. Adjusting for relevant risk factors, carotid atherosclerotic plaque formation rate in the Pre-HT was as 2.37 times as that of NT (95% CI: 1.42 N 3.95, P 〈 0. 01 ), difference of plaque formation rate between Pre-HT and HT was not significant ( P 〉 0. 05 ). Echolucent plaques were more prevalent in Pre-HT population than in HT population. Conclusions Prehypertension is associated with high risk of carotid atherosclerotie plaque formation and carotid atheroselerotic plaque formation are common among patients with the prehypertension in a middle-aged and elderly population.
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2009年第12期734-737,共4页 Chinese Journal of Nervous and Mental Diseases
基金 广东省科技计划项目资助(项目编号:2007B031502003) 中山大学附属第一医院优秀青年人才支持计划项目(编号:18700112)
关键词 高血压前期 颈动脉 斑块 社区 中老年 Prehypertension Carotid Plaque Community Middle-aged and elderly
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参考文献12

  • 1Fang XH, Zbang XH, Yang QD, et al. Subtype hypertension and risk of stroke in middle-aged and older Chinese: a 10-year follow- up study[ J]. Stroke, 2006, 37 ( 1 ) :38 - 43.
  • 2Conen D, Ridker PM, Buring JE, et al. Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study[ J]. BMJ, 2007, 335 (7617) :432 -440.
  • 3王薇,赵冬,孙佳艺,刘静,刘军,秦兰萍,刘飒,吴兆苏.中国正常高值血压人群的心血管病发病危险[J].中华高血压杂志,2007,15(12):984-987. 被引量:99
  • 4Kokubo Y, Kamide K, Okamura T, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort: the Suita study[ J]. Hypertension, 2008, 52 (4) : 652 - 659.
  • 5Chobanian AV, Bakris GL, Black HR, et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure [ J ]. Hypertension, 2003, 42 (6) :1206 - 1252.
  • 6Lammie GA, Sandercock PA, Dennis MS. Recently occluded intracranial and extracranial carotid arteries. Relevance of the unstable atherosclerotic plaque [ J ]. Stroke, 1999, 30 (7) : 1319 - 1325.
  • 7Ebrahim S, Papacosta O, Whincup P, et al. Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women. The British Regional Heart Study[J]. Stroke, 1999, 30(4) :841 -850.
  • 8Riccioni G, De Santis A, Cerasa V, et al. Atherosclerotic plaque formation and risk factors [ J 1. Int J Immunopathol Pharmacol, 2003, 16(1) :25 -31.
  • 9Dzan VJ. Atherosclerosis and hypertension: mechanisms and interrelationships [ J ]. J Cardiovasc Pharmacol, 1990, 15 ( S 5 ) : S59 - 64.
  • 10Rafflenbeul W. Hypertension treatment and prevention of new atherosclerotic plaque formation[ J ]. Drugs, 1994, 48 ( S 1 ) : 11 - 15.

二级参考文献10

  • 1王薇,赵冬,刘静,孙佳艺,吴桂贤,曾哲淳,刘军,秦兰萍,吴兆苏.中国35~64岁人群血压水平与10年心血管病发病危险的前瞻性研究[J].中华内科杂志,2004,43(10):730-734. 被引量:147
  • 2孙佳艺,赵冬,王薇,刘静,吴桂贤,王文化,李岩,吴兆苏.北京地区2740人的血压水平10年(1992-2002)变化情况[J].高血压杂志,2005,13(2):115-119. 被引量:130
  • 3[1]Prospective Studies Collaboration.Age-specific relevance of usual blood pressure to vascular mortality:a meta-analysis of individual data for one million adults in 61 prospective studies[J].Lancet,2002,360:1903-1913.
  • 4[3]Chobanian AV,Bakris GL,Black HR,et al.National heart,lung and blood institute joint national committee on prevention,detection,evaluation,and treatment of high blood pressure; national high blood pressure education program coordinating committee.The seventh report of the joint national committee on prevention,detection,evaluation,and treatment of high blood pressure:the JNC 7 report[J].JAMA,2003,289:2560-2572.
  • 5[5]World Health Organization.Multination monitoring of treads and determinants in cardiovascular disease (MONICA project) and manual of operation[M].Cardiovascular Disease Unit,Geneva,1993.
  • 6[6]Liszka HA,Mainous III AG,King DE,et al.Prehypertension and cardiovascular morbidity[J].Ann Fam Med,2005,3:294-299.
  • 7[7]Vasan RS,Larson MG,Leip EP,et al.Impact of high-normal blood pressure on the risk of cardiovascular disease[J].N Engl J Med,2001,345:1291-1297.
  • 8[8]Mainous AG,Everett CJ,Liszka H,et al.Prehypertension and mortality in a nationally representative cohort[J].Am J Cardiol,2004,94:1496-1500.
  • 9[9]Hsia J,Margolis KL,Eaton CB,et al.Prehypertension and cardiovascular disease risk in the women's health initiative[J].Circulation,2007,115.855-860.
  • 10[10]Qureshi AI,Suri MFK,Kirmani JF,et al.Is prehypertension a risk factor for cardiovascular diseases[J].Stroke,2005,36:1859-1863.

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