摘要
目的:研究乳腺良恶性组织中尿纤溶酶原激活物(uPA)的表达及临床意义。方法:采集乳腺腺瘤23例,乳腺癌109例,利用免疫组织化学方法检测uPA的表达情况。结果:uPA在乳腺癌和乳腺腺瘤中表达率分别为49.54%和21.73%,两组差异有显著性(P<0.05)。浸润性癌组阳性率高于非浸润性癌组(P<0.05),髓样癌组高于浸润性导管癌组(P<0.05),有淋巴结转移组阳性率高于无转移组,差异有显著性(P<0.05)。结论:uPA阳性率与患者病理类型及有无淋巴结转移有关。检测uPA在乳腺癌中表达,可以提示预后并对肿瘤的治疗方案选择有指导作用。
Objective：To investigate the significance of urinary plasminogen activator expression in adenoma and cancer of breast.Methods：uPA was deteced by immunohistochemistry in 109 cases with breast cancer and 23 cases with adenoma.Results：The positive rates of uPA were 49.54%（54/109） and 21.73%（5/23） respectively in breast ancer and adenoma.The positive rates of infiltrating cancer were higher than that of non-invasive carcinoma（P〈0.05）,the positive rates of medullary carcinoma was higher than that of infitrating ductal carcinoma（P〈0.05）,the positive rates of lymphatic metastasis were higher than that of Lymph nodes without moving（P〈0.05）.Conclusion：The positive rates of uPA were associated with age,pathology type and lymph node metastasis.The detemination of uPA might be useful for estimating prognosis and treating breast cancer.
出处
《河北北方学院学报（医学版）》
2009年第6期20-22,共3页
Journal of Hebei North University:Medical Edition
关键词
乳腺肿瘤
腺瘤
尿纤溶酶原激活物
免疫组织化学
Breast Neoplasms, Adenoma, Urinary plasminogen activator, Immunohistochemistry
