摘要
目的探讨脾窦岸细胞血管瘤的临床特征及组织学、免疫组化特点。方法对2例脾窦岸细胞血管瘤的临床资料、影像学检查、组织学检查、免疫组化结果进行分析,并复习文献。结果脾窦岸细胞血管瘤的临床症状和影像学表现不典型,组织病理学特征表现为瘤结节位于脾红髓内,由相互吻合的血管腔构成,呈迷路样分布,常有乳头样结构突入腔内,部分细胞高柱状似鞋钉,部分胞质丰富似组织细胞,胞质内可见含铁血黄颗粒。免疫组化FⅧAg、CD34、CD31、CD68、AAT、Lys均为阳性。结论脾窦岸细胞血管瘤是一种罕见的脾血管源性肿瘤,诊断主要依靠组织病理学及免疫组化,治疗以脾脏切除为主,因可合并恶性肿瘤,应进行仔细检查及密切随访。
Objective To investigate the clinical feature, histological cbaracterestics and immunohistochemical characterstics of littoral cell angioma of spleen. Methods The clinical data of two patients with littoral cell angioma were analyzed retrospectively. In a while, the radiological examination and morphologic characteristics were studied and some specific antigens were detected. Results The clinical feature and radiographic appearance of the tumor were atypical. Histologically, littoral cell angioma was located in red pulp and characterized by anastomosing vascular channels interspersed with dilated vascular spaces and pseudopapillary foci. The vascular channels were lined by spindle or plump, bland-looking cells, and hemosiderin was commonly found in the cytoplasm of some tumor ceils. FVSAg, CD34, CD31, CD68, AAT and Lysozyme showed immunopositive expression in the cases. Conclusion Littoral cell angioma is a rare vascular lesion of the spleen. Its diagnosis is on the basis of microscopic and immunohistochemical features. Operative treatment is the effective measure for the patients. The disease may be associated with maligant neoplasms, so close follow-up and careful investigation are strongly recommended.
出处
《肿瘤基础与临床》
2009年第5期423-425,共3页
journal of basic and clinical oncology
关键词
脾肿瘤
窦岸细胞血管瘤
病理诊断
spleen tumor
littoral cell angioma
pathological diagnosis
