摘要
目的探讨骨外尤文氏肉瘤的临床病理学特点。方法对2例骨外尤文氏肉瘤进行临床病理分析并复习相关文献。结果1例未行化疗在根治手术后6个月发生转移,7个月后死亡。1例经过根治性手术后又进行了1个疗程的辅助化疗,在13个月后发生转移,15个月后死亡。病理组织学显示:肿瘤由大小和形态较一致的小圆细胞排列成片状、小叶状或巢状,较少或无菊形团(Ho-mer-wright)结构。免疫组织化学:Vim、CD99阳性。结论骨外尤文氏肉瘤是一种少见的软组织恶性小细胞性肿瘤,恶性度高,若不行辅助化疗,早期便可转移至肺或其他脏器,预后差。
Objective To study the clinicopathologic features of the etraskeletal Ewing＇ s sarcoma. Methods The clinicopathologic features of 2 cases of EOE were analyzed. The related literature also had been reviewed. Results One patient underwent surgery without muhiagent chemotherapy, developed late metastases in 6 months from diagnosis and died in 7 months, one patient underwent multiagent chemotherapy （VAC） after surgery, and developed late metastases in 13 months from diagnosis and died at 15 months. Microscopically,undifferentiation small round cell＇ s were arranged in variable patterns of diffuse growth, lobular or nested, was rare or no Homer-wright rosette structures could be observed. Immunohistochemistry,Vimentin and were CD99 expressed in all the tumor cells. Conclusion EOE is an uncommon malignant round cell tumor that arises from the soft tissue. If no adjuvant chemotherapy, early metastases of lung or other organs can be presented, and the prognosis is poor.
出处
《肿瘤基础与临床》
2009年第5期430-432,共3页
journal of basic and clinical oncology
关键词
病理诊断
骨外尤文氏肉瘤
免疫组织化学
pathologic diagnosis
extraskeletal Ewing＇ s sarcoma
immunohistochemistry
