摘要
目的探讨慢性尿酸性肾病的临床特点及疗效。方法收集本院肾内科住院确诊为慢性尿酸性肾病患者35例,回顾性分析其临床特点、伴发病情况及治疗。结果35例中,男31例,女4例;平均年龄61.5岁,平均病程12.3年。有痛风家族史4例。肾外表现,伴急性痛风性关节炎26例,伴痛风结节10例。血尿23例,蛋白尿24例,低比重尿15例,慢性肾功能不全27例。伴发病情况,高脂血症18例,高血压25例。治疗上,急性期23例使用非甾体类消炎药,10例使用秋水仙碱,8例使用激素。慢性期25例应用别嘌呤醇降尿酸,用立加利仙7例促尿酸排泄。降压治疗10例使用科素亚。10例最终达终末期肾病,予透析治疗。结论痛风发病率呈上升趋势,应重视慢性高尿酸血症导致的肾脏损害。
Objective To analyze clinical characteristics and therapy of gouty nephropathy. Methods The clinical data of 35 patients with gouty nephropathy were retrospectively analyzed and summarized. Results Thirty-five cases included 31 cases of men and four cases of women. Their average age were 61.5 years old, and the average duration were 12.3 years. There were four cases of a family history of gout. Outside the renal manifestations, acute gouty arthritis with 26 cases and 10 cases of tophus were observed. Among these patients, 23 cases had hematuria, 24 cases had proteinuria, and 15 had low gravity urine. Chronic renal insufficiency in 27 cases. Eighteen cases were accompanied with hyperlipidemia, 25 with hypertension. 23 cases were used non steroidal anti-inflammatory drugs for controlling acute inflammatory, 10 cases were used colchicine, eight cases were used corticosteroids. Chronic phase 25 cases were used with allopurinol for interrupt uric synthesis, seven cases were used with benzbromarone. Losartan used for the treatment of hypertension in 10 cases. 10 cases developed end stage renal disease and got dialysis treatment. Conclusion The incidence of gout has been increasing. We should pay attention to kidney disease caused by chronic hyperuricemia.
出处
《福建医药杂志》
CAS
2009年第6期18-20,共3页
Fujian Medical Journal
