摘要
作者采用双波长紫外分光光度法对磁共振成像造影剂钆喷酸葡胺注射液进行了定量研究。应用双波长紫外分光光度法，选择测量波长组合λ２＝２７４．１ｎｍ，λ１＝３２０．０ｎｍ，无需分离被测组分，直接对钆喷酸进行定量分析。在１．０９６～５４．８０ｍｇ／ｍｌ范围内，吸光度差值与钆喷酸浓度呈线性关系，检测限为０．５２６３ｍｇ／ｍｌ，ｒ＝０．９９９７，平均回收率为９９．４％，ＲＳＤ为０．８５％（ｎ＝５）。本研究为钆喷酸含量测定提供了一种新方法。
The experimental conditions for determining gadopentetate in gadopentetate dimeglumine injection by double wavelength ultraviolet spectrophotometric method were studied.The △A value of standard sample was proportional to gadopentetate concentration at 274.1 nm and 320.0 nm(r=0.9997),with a liner range of the concentration from 1.096mg/ml to 54.80 mg/ml.The detection limit of gadopentetate was 0.5263 mg/ml,the average recovery 99.4% and the RSD value 0.85%(n=5).The new menthod is simple and rapid to use,and accurate in determination of gado pentetate level in gadopentetate dimeglumine injection.
出处
《第一军医大学学报》
CSCD
1998年第3期208-209,共2页
Journal of First Military Medical University
关键词
紫外分光光度法
钆喷酸
造影剂
NMR
成像
double wavelength ultraviolet spectroscopy
gadopentetate dimeglumine injection
gadopentetate
