摘要
目的:比较马钱子碱脂质体与游离药物溶液的药物动力学。方法:大鼠尾静脉给药,以士的宁为内标,用HPLC法测定大鼠血浆中马钱子碱的浓度,用3p97程序拟合房室模型并计算药物动力学参数。结果:马钱子碱脂质体大鼠尾静脉单次给药血药浓度经时曲线符合三室模型,而游离马钱子碱溶液符合二室模型。与游离药物相比,马钱子碱脂质体的AUC(增加3.75倍)、CL、T1/2(延长了4.78倍)等药动学参数有显著改善。结论:马钱子碱脂质体具有比马钱子碱溶液更为理想的药物动力学性质。
Objective： To compare pharmacokinetic properties of free brncine and liposomal brucine. Methods： Rats were intravenous injected with brueine solution or brusine liposomes. Strychnine was used as an internal control. Plasma concentrations were detected by HPLC method. The pharmacokinetie parameters were calculated and analyzed by 3p97 pharmacokinetie program. Results ： The plasma concentration - time curves of brusine solution liposomes obeyed a three - compartment model, while brueine solution obeyed a two - compartment model. AUC, CL, T1/2 and some other parameters of brucine liposomes were significantly improved. Conclusion： Compared with brueine solution, the brueine liposomes possess more satisfactory pharmacokinetic characteristics.
出处
《中华中医药学刊》
CAS
2010年第1期69-71,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30701111)
