摘要
目的探讨超声造影(CEUS)定量分析肝细胞癌(HCC)的血流动力学参数与肿瘤病理分级的相关性。方法对77个HCC病灶进行CEUS检查和脱机定量分析,得到下列定量参数:曲线峰值减半斜率(SD)、强度增量(ISI)、曲线下面积(AUC)和灌注系数(BF)以及肿瘤与肝实质相应参数相比所得的标化值sISI、sAUC和sBF。根据Edmonson病理分级进行对比分析研究。结果SD、AUC和BF以及标化值sISI、sAUC和sBF在不同分化组间差异有统计学意义(P<0.05)。AUC、BF、sISI、sAUC和sBF分别与病理分级呈负相关(P<0.05)。分化好的HCC灌注值更高(P<0.05)。结论CEUS定量分析能间接反映HCC的分化程度,具有揭示恶性肿瘤的生物学行为的潜能。
Objective To investigate the relationship between hemodynamic parameters from quantitative analysis of contrast-enhanced ultrasonography（CEUS） on hepatocellular carcinoma（HCC） and pathological tumor differentiated grades.Methods Seventy-seven HCC lesions were examinated and off-line analyzed with dynamic images.Quantitative parameters such as slope of decrease to half of peak（SD）,increased signal intensity（ISI）,area under the curve（AUC） and blood flow coefficient（BF） were acquired,and the standardized values（sISI,sAUC and sBF） included the ratio of parameters from tumor to those from hepatic parenchyma.These quantitative parameters were correlated with tumor grades according to Edmonson criteria.Results There was significant difference（P〈0.05） of SD,AUC and BF,as well as standardized values（sISI,sAUC and sBF） between different grades of HCC.AUC,BF,sISI,sAUC and sBF were negative correlated with differentiated grades,respectively（P〈0.05）.Well-differentiated HCC had significantly higher perfusion values than HCC of other grades（P〈0.05）.Conclusion Quantitative analysis of CEUS can assess differentiation of HCC indirectly,and might reveal biological behavior of malignant tumors.
出处
《中国医学影像技术》
CSCD
北大核心
2009年第12期2243-2245,共3页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(30872409)
关键词
超声检查
介入性
肝肿瘤
肿瘤分级
Ultrasonography
interventional
Liver neoplasms
Tumor grades
