摘要
目的:研究老年高血压患者尿微量蛋白、内皮素(ET)、C反应蛋白(CRP)的水平变化,为观察早期老年高血压患者靶器官损害探索道路。方法:将130例老年原发性高血压患者根据血压水平分为3组,40例血压正常者为对照组,所有研究对象入选时血尿素氮、肌酐和24h尿蛋白总量均在正常范围内。取晨尿用免疫散射法测定尿白蛋白(Alb)、α1-微球蛋白(α1-MG)、β2微球蛋白(β2-MG),空腹血测定ET、CRP。结果:随着血压升高,各项尿微量蛋白指标及ET、CRP均有增高趋势。结论:尿微量蛋白、ET、CRP均可作为高血压靶器官损害的监测指标,其中内皮素在高血压的早期靶器官损害中更有检测意义。结论:有必要对基层医院及非药学的医务人员进行长期的ADR专业知识的宣传和培训,以提高医务人员对ADR知识的整体认知水平。
Objective： To study the changes in endothelin （ET）, C-reactive protein （CRP） and urine micropro- rein in the elders with essential hypertension to explore the road for observating early target-organ damages in aged patients with hypertension. Method： 130 elderly hpertensive patients with normal serum urea nitrogen（ BUN）, creatinine （Cr） and 24h urine protein were divided into three groups according to the levels of their blood pressure, and another 40 healthy elderly persons were organized in the controlled group. Urine albumine （Alb） , α1-microglobulin （α1-MG） and β2-micro- globulin （β2-MG） were determined by immune scattering. ET and CRP were determined in fasting. Result： In the four groups, the levels of urine microprotein, ET and CRP increased synchronously with the blood pressure levels. Conclusion： Urine microprotein, ET and CRP can be used as monitors for target organ damages in hypertension. ET was very useful for the monitor of the damages in the earlier stage.
出处
《药物流行病学杂志》
CAS
2010年第1期6-8,共3页
Chinese Journal of Pharmacoepidemiology
关键词
尿微量蛋白
高血压
内皮素
C反应蛋白
Urine microprotein
Hypertension
Endothelin
C-reactive protein
