摘要
目的：观察氯胺酮不同浓度在不同时间对离体Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠乳头肌收缩性能的影响。方法：１０条乳头肌分别给予氯胺酮１０、２０、３０、４０μｇ／ｍｌ，观察等长张力峰值（ＰＴ），张力上升最大速度（ｄＴ／ｄｔｍａｘ）、张力下降最大速度（－ｄＴ／ｄｔｍａｘ）和心肌收缩成份缩短速度（Ｖｃｅ）在用药后不同时间的变化。结果：当氯胺酮的浓度大于２０μｇ／ｍｌ，特别是达到４０μｇ／ｍｌ时，ＰＴ、±（ｄＴ／ｄｔｍａｘ）５ｍｉｎ内即明显下降（Ｐ＜０．０５），１０ｍｉｎ时分别下降５７．７％±３．２％，５７．３％±４．１％和５８．２％±３．８％，差异非常显著（Ｐ＜０．０１），１５ｍｉｎ即下降为零，有极显著性差异（Ｐ＜０．００１）。
Objective:To evaluate the effect of various concentration of ketamine at different time on myocardial contractility.Methods:Ten left ventricular papillary muscles in vitro were administrated respectively with 10、20、30、40μg/ml of ketamine.The contractility parameters of peak twitch tension(PT),maximum rate of contraction (dT/dt max ),maximum rate of relaxation ( dT/dt max ) and velocity of shortening of myocardial muscle contractility element (V ce ) were measured.The changes of myocardial contractility were observed at 2,5,10,15min after the virous concentrations.Results:Ketamine induced a slight change in PT,±dT/dt max ( P> 0 05) in the concentrations ranged from 10μg/ml to 30μg/ml.PT,dT/dt max and dT/dt max at 5 min decreased significantly by 57 7%±3 2%,57 3%±4 1% and 58 2%±3 8%,respectively in 40μg/ml of ketamine.The complete inhibition occured and lasted for 15min when concentration of ketamine was 40μg/ml.Conclusion:Cardiovascular depression observed with ketamine is related to its intrinsic myocardial depression.
出处
《临床麻醉学杂志》
CAS
CSCD
1998年第5期288-288,共1页
Journal of Clinical Anesthesiology
关键词
氯胺酮
乳头肌
收缩性能
Katamine Papillary muscle Contractility
