摘要
目的:观察正常人和肝纤维化与肝硬化患者肝组织中趋化因子Fractalkine的表达.方法:采用ELISA法分别检测9例正常人、10例肝纤维化及11例肝硬化患者肝组织中的Fractalkine含量.结果:肝纤维化组和肝硬化组Fractalkine浓度均显著高于正常对照组(13.72±5.59ng/g,14.70±3.52ng/gvs4.84±3.72ng/g,均P<0.05),肝纤维化组和肝硬化组的Fractalkine浓度差异无统计学意义.结论:肝脏发生纤维化损伤时Fractalkine表达增强,至肝硬化阶段仍维持较高水平.
AIM： To investigate the intrahepatic levels of chemokine Fractalkine in healthy individuals and patients with hepatic fibrosis and cirrhosis.
METHODS： Hepatic tissues were obtained in surgery from 9 normal persons, 10 patients with fibrotic liver, 11 patients with cirrhosis. The content of Fractalkine in hepatic tissue was assayed by ELISA.
RESULTS： The intrahepatic levels of Fractalkine in patients with hepatic fibrosis and cirrhosis were remarkably higher than that in healthy individuals （13.72 ± 5.59 ng/g and 14.70 ± 3.52 ng/g vs 4.84 ± 3.72 ng/g, respectively; both P 〈 0.05）. No significant difference was noted in intrahepatic level of Fractalkine between patients with hepatic fibrosis and cirrhosis.
CONCLUSION： Intrahepatic level of Fractalkine increases with the aggravation of hepatic fibrosis and remains high in liver cirrhosis.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第33期3456-3459,共4页
World Chinese Journal of Digestology
基金
广州市科技攻关计划基金资助项目
No2007Z3-E0371~~
