摘要
肿瘤干细胞已经被证实存在于一些肿瘤组织中,而肝癌干细胞是否存在仍未得到确切的结果.通过实验,研究人员对于肝癌干细胞的来源提出了两个假说:成熟肝细胞的去分化与肝干细胞的"成熟受阻".目前后者是较为公认的肝癌形成途径.同时,为了得到肝癌干细胞存在的直接证据,研究人员一直致力于其表面标志物的研究,希望通过得到理想的标志物来鉴定分选出肝癌干细胞.SP细胞与肝癌干细胞的研究也是目前研究的热点.因此,肝癌干细胞的研究将会对肝癌的诊断和治疗产生重大的意义.
Cancer stem cells have been identified in various human tumors. However, it remains controversial as to whether or not liver cancer stem cells （LCSCs） exist until now. There are two hypotheses to explain the origin of liver cancer stem cells： the dedifferentiation of mature hepatocytes and the maturation arrest of liver stem cells. Now, the latter is generally acknowledged to be the better one. To obtain direct evidence for the existence of LCSCs, many researchers focus their studies on the surface markers on LCSCs to identify ideal markers for isolation of LCSCs. Besides, the relationship between side population （SP） cells and LCSCs also attracts much attention. Therefore, the study of LCSCs is probably of great significance for the diagnosis and treatment of liver cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第36期3704-3710,共7页
World Chinese Journal of Digestology
基金
南京市卫生局重点基金资助项目
No.ZKX08025~~
关键词
肝癌干细胞
表面标志物
侧群细胞
靶向治疗
Liver cancer stem cells
Surface marker
Side population cells
Targeted therapy
