摘要
采用琼脂稀释法测定了５种抗菌剂对２０１株淋病奈瑟氏球菌的最低抑菌浓度（ＭＩＣ）。结果检出４株为产β－内酰胺酶菌株（ＰＰＮＧ），对青霉素和四环素的耐药率分别为５７．２％和８２．６％，其ＭＩＣ９０均已超过耐药界限（ＭＩＣ＝１μｇ／ｍｌ）。３５株耐环丙沙星，其中１５株同时对青霉素和四环素有耐药性。对大观霉素和头孢曲松的敏感性最高，分别为９９％和１００％，但检出２株耐大观霉素菌株，头孢曲松ＭＩＣ５０、ＭＩＣ９０明显高于国内外报道。
Minimum inhibitory concentrations (MIC) of antimicrobial agents, penicillin, tetracycline, spectinomycin, ciprofloxacin and ceftriaxone, to 201 strains of Neisseria gonorrhoeae were determined by agar dilution method. Results showed that 4 strains of N.gonorrhoeae produced β lactamase (penicillinase producing Neisseria gonorrhoeae , PPNG); 119(57.2%) and 166(82.6%) were resistant to penicillin (MIC≥1μg/ml) and tetracycline (MIC≥1μg/ml), respectively, and both of the MIC 90 were higher than the resistant standard (MIC≥1μg/ml). Out of 35 ciprofloxacin resistant N.gonorrhoeae strains, 15 strains were multiresistant to penicillin and tetracycline. The susceptibilities to spectinomycin and ceftriaxone were higher, 99% and 100%, respcetively; but present of 2 strains with spectinomycin resistant and ceftriaxone MIC 50 and MIC 90 higher than that reported at home and abroad were particularly noteworthy.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1998年第5期377-379,382,共4页
Chinese Journal of Antibiotics
基金
1997年广东省卫生厅资助
