摘要
目的:观察加味竹叶石膏汤对急性放射性食管炎的防治作用。方法:120例确诊为肺癌、食管癌及纵隔肿瘤并采用放疗的患者随机分为治疗组80例与对照组40例。治疗组自放疗始口服加味竹叶石膏汤(1剂/d,200mL/次,2次/d)至放疗结束。对照组自放疗始口服思密达3g,2次/日,早晚服用,直至放疗结束。两组病例均采用电子直线加速器高能X线常规分割外照射,照射野包括食管在内,放疗总剂量>40Gy,食管照射长度>10cm。结果:治疗组1、2、3级急性放射性食管炎的发生率分别为38.8%、15%、0%;与对照组的75.0%、52.5%、7.5%比较差异有统计学意义(P<0.05)。治疗组急性放射性食管炎的发生时间为放疗后(19.86±0.34)d,较对照组(16.73±0.28)d延迟(P<0.001)。结论:加味竹叶石膏汤能减少急性放射性食管炎的发病率,推迟发病时间,对急性放射性食管炎有一定的防治作用。
Objective： To investigate the prevention and treatment effects of Modified Lophatheri and Gypsi Fibrosi Decoction on acute radiation esophagitis. Methods： 120 patients with lung cancer, esophageal cancer or mediastinal tumor and receiving radiotherapy were divided into the treatment group（80 cases）and the control group（40 cases）randomly. From the beginning to the end of radiotherapy, the patients in the treatment group took orally the Modified Lophatheri and Gypsi Fibrosi Decoction（1 dose daily, 200mL each time, twice per day）and those in the control group took Dioctahedral smectite （ 3g, twice per day）. Each patient in the two groups was given routine high-energy x-ray fractionation external irradiation with linear electron accelerator （ exposure field covered esophago, total radiotherapy dose 〉 40 Gy, length of irradiated esophago 〉 10cm ） . Results： In the treatment group, the incidence rates of grade 1, 2 and 3 acute radiation esophagitis were 38.8%, 15% and 0% respectively, and in the control group, they were 75%,52.5% and 7.5%, which indicated statistical difference（P〈 0.05）. And the occurrence time of acute radiation esophagitis in the treatment group[（19.86±0.34） d post the radiotherapy] was also more delayed than that in the control group（16.73±0.28）d post radiotherapy（P〈 0.001）. Conclusion： Modified Lophatheri and Gypsi Fibrosi Decoction could decrease the incidence rate of acute radiation esophagitis and delay its occurrence time, which showed that Modified Lophatheri and Gypsi Fibrosi Decoction had some prevention and treatment effects on acute radiation esophagitis.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2010年第1期59-62,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
急性放射性食管炎
中医药疗法
竹叶石膏汤
Acute radiation esophagitis
Chinese traditional medicine therapy
Lophatheri and Gypsi Fibrosi Decoction
