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Ki-67在血液肿瘤中的应用及其研究进展 被引量：2

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摘要 Ki-67是一种与细胞分裂增殖有关的核蛋白,在有丝分裂的G0和G1早期不表达,G1中期到晚期出现,S期和G2期逐渐增加,M期到最高值,随后快速降解。由于其表达量随细胞周期不同而发生改变,在细胞周期各阶段有动态变化,起一种计时分子的作用,因此被认为是评估人体肿瘤生长的一种重要工具[1]。在血液肿瘤中,有大量的原始和幼稚细胞在骨髓、淋巴结中增殖,Ki-67的检测已广泛应用于血液肿瘤的诊断,疗效监测和预后判断。本文就Ki-67在血液肿瘤中的应用及其研究进展作一综述。
作者 陈姣 贾永前 钟凌
机构地区 四川省人民医院血液科 四川大学华西医院 四川省人民医院检验科
出处 《实用医学杂志》 CAS 北大核心 2009年第22期3906-3907,共2页 The Journal of Practical Medicine
关键词 KI-67 血液肿瘤 细胞分裂增殖 细胞周期 有丝分裂 动态变化 肿瘤生长 幼稚细胞
分类号 R733 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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共引文献29

同被引文献27

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实用医学杂志
2009年 第22期

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