摘要
目的:制备原花青素柔性纳米脂质体,探索其与普通脂质体体外释药特性。方法:采用薄膜分散法制备脂质体混悬液,采用透射电镜观察其形态;以总酚的含量作为评价指标,采用动态透析法考察其在不同介质中的释药特性。结果:原花青素柔性纳米脂质体、普通脂质体体外释药特性均符合Weibull模型。结论:在没有压力条件下,原花青素柔性纳米脂质体与普通脂质体具有相似的体外释药特性。
Objective：To prepare flexible nanoliposomes with proanthocyanidins,and to explore the effect of in vitro release between proanthocyanidins flexible nanoliposomes and general nanoliposomes. Method：To prepare flexible nanoliposomes with proanthocyanidins using a film dispersion method,and investigating their characterizations using a transmission electron microscope,and the in vitro release action was studied in different dissolution mediums using dynamic dialyse method,and the content of total phenol as index. Result：The in vitro release of both proanthocyanidins flexible nanoliposomes and general nanoliposomes meet to Weibull distribution. Conclusion：Both proanthocyanidins flexible nanoliposomes and general nanoliposomes had the similar characterizations of in vitro without pressure.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2010年第2期169-172,共4页
China Journal of Chinese Materia Medica
基金
中国博士后科学基金项目(20080430532)
关键词
原花青素
柔性纳米脂质体
普通脂质体
体外释药
proanthocyanidins
flexible nanoliposomes
general nanoliposomes
drug release in vitro
