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急性冠脉综合征患者超敏C-反应蛋白、脂蛋白a、脂联素的悬浮芯片技术集成检测及其意义 被引量：5

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摘要 目的:检测急性冠脉综合征(ACS)患者血中超敏C-反应蛋白(hs-CRP)、脂蛋白a[Lp(a)]及脂联素(APN)3种蛋白因子的浓度并探讨其临床意义。方法:用悬浮芯片技术集成检测116例ACS患者(ACS组)hs-CRP、Lp(a)及APN3种蛋白因子的浓度,并与30例单纯稳定型心绞痛患者(SAP组)及35例正常人群(NC组)进行对照。结果:ACS组hs-CRP、Lp(a)较SAP组及NC组浓度均增高,APN值则明显降低(均P<0.05),其中ACS组中AMI组hs-CRP、Lp(a)浓度高于UAP组,APN值低于UAP组(均P<0.05)。ACS各亚组中预后不良患者hs-CRP、Lp(a)水平高于预后良好者(均P<0.001),而APN浓度则显著低于预后良好患者(P<0.01)。hs-CRP、Lp(a)的含量与斑块不稳定程度呈显著正相关关系(r=0.592,P<0.001;r=0.385,P<0.001),APN的含量与斑块不稳定程度则呈显著负相关关系(r=-0.627,P<0.001)。结论:hs-CRP、Lp(a)、APN可能参与ACS病变全过程,与ACS临床类型及其预后高度相关,因此可用来预测ACS的病变稳定程度和心血管事件发生的危险度,从而判断预后。
作者 张紫微 刘映峰 缪绯 李健洪 赵欢 刘芃
机构地区 南方医科大学珠江医院心血管内科
出处 《实用医学杂志》 CAS 北大核心 2010年第1期61-63,共3页 The Journal of Practical Medicine
基金 广东省科技计划项目(编号:2007B03150810)
关键词 冠状动脉疾病 C-反应蛋白 脂蛋白(A) 脂联素 悬浮芯片
分类号 R541.4 [医药卫生—心血管疾病] R512.62 [医药卫生—内科学]
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参考文献14

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实用医学杂志
2010年 第1期

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