摘要
目的;研究表柔比星(Epi)在肿瘤患者体内的药物动力学.方法:11例肿瘤患者单次iv 60mg/m^2Epi,用HPLC测定Epi血药浓度,数据用3P87药物动力学程序进行模型拟合并计算药物动力学参数.结果:Epi的药-时曲线符合三室模型,其主要药物动力学参数分别为:T_(1/2p)=(0.052±0.018)h,T_(1/2(?))=(1.25±1.18)h,T_(1/2p)=(31.1±13.7)h,Vc=(23.9±11.2)ml,AUC=(2009±429)ng·h/ml,CL=(50.1±12.1)ml/h.结论:Epi在肿瘤患者体内分布迅速,消除缓慢.
AIM:To study pharmacokinetics of epirubicin in tumor patients. METHODS;The epirubicin concentrations in serum were determined by HPLC method following a single bolus dose of (average )60mg/m2 was injected intravenously to 11 tumor patients. The 3P87 program was used to calculate the pharmacokinetic parameters. RESULTS;It was found that the serum concentrations-time curves were fitted to a three-compartment model. The main pharmacokinetic parameters were as follow;T1/2p= (0. 052±O. 018)h,T1/2a= (1.25±l.18)h, T1/2?β = (31.1±13. 7)h,Vc=(23. 9±11. 2)ml,AUC= (2 009±429)ng · h/ml,CL = (50.1± 12. l)ml/h.CONCLUSION;The distribution of epirubicin was rapid and the elimination was slow. This study will provide a scientific basis for the clinical applications.
出处
《中国临床药学杂志》
CAS
1998年第4期154-157,共4页
Chinese Journal of Clinical Pharmacy
关键词
表柔比星
血药浓度
HPLC
药物动力学
肿瘤
epirubicin
blood concentrations
high performance liquid chromatogra-phy
pharmacokinetics
