摘要
目的观察合并中重度阻塞性睡眠呼吸暂停综合征(OSAS)合并冠心病(CHD)患者冠状动脉(简称冠脉)造影特点。方法应用冠脉造影观察中重度OSAS合并CHD患者(n=92)以及非OSAS合并CHD患者(n=100)冠状动脉病变特点,并应用酶联免疫方法测定两组患者血浆内皮素-1(ET-1)及C反应蛋白(CRP)浓度。结果中重度OSAS合并CHD患者在冠状动脉血管病变支数、闭塞性病变总数、血管钙化、血管严重迂曲、存在桥侧支所占比例均明显高于非OSAS组(P<0.05),闭塞段血管长度也显著高于非OSAS组,两组的TIMI血流情况差异亦有统计学意义(P<0.01);中重度OSAHS合并CHD患者血浆ET-1、CRP均较对照组显著增高(121.57±31.8 vs 68.23±23.12,P=0.0032;12.75±3.48 vs 5.74±2.19,P=0.029)。结论中重度OSAS合并CHD患者较非OSAS合并CHD患者有更重的冠状动脉病变,这可能与内皮功能损伤及炎性反应异常有关。
Objective To analyse the pathogenic angiograpbic manifestation of coronary heart disease with obstructive sleeping apnea syndrome. Methods The clinical and coronary angiographic data,endothelia-1 （ET -1 ） and C reactive protein CRP were com pared among the patients with coronary heart disease（CHD） with（n= 92） orwithout（n =100） obstructive sleeping apnea syndrome （OSAS）.Apnea hypopnea index（AHI） of 20 was used as cutoff value. Results OSAS group had more coronary lesions compared to the CHD patients without OSAS （P〈0.05;P〈0. 01 ）. Furthermore, the value of ET -1 and CRP were both higher in OSAS group（121.57±31.8 vs 68.23±23. 12, P=0. 0032 ;12. 75 ± 3. 48 vs 5.71±2. 19,P=0. 029）. Conclusion OSAS patients have more coronary lesions compare to the CHD ,oalients without OSAS. These maybe partly contribute to vascular endothelia dysfunc tion and abnormal inflammation.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第2期171-172,176,共3页
Chongqing medicine
