期刊文献+

口服避孕药联合二甲双胍治疗多囊卵巢综合征患者子宫内膜不典型增生 被引量:18

原文传递
导出
摘要 多囊卵巢综合征(PCOS)患者是子宫内膜增生性病变的高危人群。因其稀发排卵,患者的子宫内膜长期暴露于雌激素刺激下而缺乏孕激素的对抗,内膜腺体持续生长,可能出现腺体过度增生,甚至细胞核增大、深染等不典型的癌前变化。治疗子宫内膜不典型增生,常采用人工合成的高效孕激素以转化子宫内膜;但有部分患者对孕激素治疗不敏感,治疗失败率可高达30%。
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2010年第1期56-57,共2页 Chinese Journal of Obstetrics and Gynecology
  • 相关文献

参考文献2

二级参考文献20

  • 1李昕,林金芳.肥胖型多囊卵巢综合征患者临床及内分泌代谢特征的研究[J].中华医学杂志,2005,85(46):3266-3271. 被引量:139
  • 2林金芳,李昕,朱铭伟.多囊卵巢综合征的分型探讨[J].中华妇产科杂志,2006,41(10):684-688. 被引量:74
  • 3Bridger T,MacDonald S,Baltzer F,et al.Randomized placebo-controlled trial of metformin for adolescents with polycystic ovary syndrome[J].Arch Pediatr Adolesc Med,2006,160(3):241-246.
  • 4Sahin I,Serter R,Karakurt F,et al.Metformin versus flutamide in the treatment of metabolic consequences of non-obese young women with polycystic ovary syndrome:a randomized prospective study[J].Gynecol Endocrinol,2004,19 (3):115-124.
  • 5Eisenhart S,Schwarzmann N.Early effects of metformin in women with polycystic ovary syndrome:a prospective randomized,double-blind,placebo-controlled trial[J].J Clin Endocrinol Metab,2006,91:946-952.
  • 6Antonio LM,Alfredo CA,Gaspare S,et al.Metformin treatment of PCOS during adolescence and the reproductive period[J].Eur J Obstet Gynecol Reprod Biol,2005,121 (1):3-7.
  • 7Lehmann JM,Moore LB,Smith-Oliver TA,et al.An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor-γ[J].J Biol Chem,1995,270 (22):12953-12956.
  • 8Garmes HM,Tambascia MA,Zantut-Wittmann DE.Endocrinometabolic effects of the treatment with pioglitazone in obese patients with polycystic ovary syndrome[J].Gynecol Endocrinol,2005,21 (6):317-323.
  • 9Ortega-Gonzalez C,Luna S,Hernandez L,et al.Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese,insulin-resistant women with polycystic ovary syndrome[J].J Clin Endocrinol Metab,2005,90 (3):1360-1365.
  • 10Glueck CJ,Moreira A,Goldenberg N,et al.Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin[J].Hum Reprod,2003,18(8):1618-1625.

共引文献78

同被引文献205

引证文献18

二级引证文献158

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部